Results 111 to 120 of about 612,434 (304)
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Coral communities and reefs of Ballena Marine National Park, Pacific coast of Costa Rica
Ciencias Marinas, 2005 The coral communities and reefs at Ballena Marine National Park, on the southern Pacific coast of Costa Rica, were studied using three 10-m long transects per site, parallel to the coast, with 1-m2 quadrants.
Juan José Alvarado +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
FEBS Open Bio, EarlyView.Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar +4 more
wiley +1 more source
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Aging and Cancer, EarlyView.Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
Endoparasites Determined by Fecal Examination in Sheep in Erzurum Province
Türkiye Parazitoloji Dergisi, 2019 Objective:The aim of the current study was to determine the presence and prevalence of Eimeria and helminth species in sheep raised in Erzurum province by using fecal examination.Methods:Faecal samples were collected from a total of 784 sheep raised in ...
Muzaffer Akyüz +4 more
doaj +1 more source
Aging and Cancer, EarlyView.Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source
Remote SensingHigh-resolution water quality maps derived from imaging spectroscopy provide valuable insights for environmental monitoring and management, but the processing of all pixels of large datasets is extremely computationally intensive and limits the speed of ...
Nicholas R. Vaughn +4 more
doaj +1 more source
Erosion and Sedimentation Processes at Northern Waihi Beach [PDF]
, 2009 The northern sector of Waihi Beach is an example of chronic erosive tendency. The sediment deficit along the area of beach fronting the seawall means that there is often no beach at high tide.
Bear, Alison Louise
core +1 more source