Results 91 to 100 of about 377,749 (305)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
, 1950 Caption says, "5-AL-1292. Sedimentation - Altus Reservoir. View looking east from R17R along sedimentation Range 17, showing delta of sediment.
Brummett, R. C.
core
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Problems of sedimentation in small dams in Zambia [PDF]
, 1997 Journal ArticleAn inventory of small dams in Zambia and the results of a preliminary analysis of sediment loads for rivers and reservoirs are reported. A regression approach was used to determine relationships between drainage area and sediment load for ...
Sichingabula, Henry
core +1 more source
, 2010 Sedimentation is a classic method of biochemistry that provides first‐principle hydrodynamic and thermodynamic information about the purity, size, shape, molar mass, association energy, association stoichiometry and thermodynamic nonideality of molecules
Laue, Thomas M., Thomas Maxon Laue
core +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Despite the mechanisms of reservoir sedimentation being well known for a long time, sustainable and preventive measures are rarely taken into consideration in the design of new reservoirs.
core +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Estimation of design flow rates for bridge and tunnel engineering for estuaries and coasts
Shui kexue jinzhan, 2019 During the design process of sea-crossing bridges and tunnels,it is necessary to estimate the design flow velocities at different recurrence periods for the project location.
PAN Junning +3 more
doaj +1 more source