Results 71 to 80 of about 220,642 (267)

Research progress on the failure mechanism of ecological slope protection under multi-factor coupling in the Lower Yellow River

Shui kexue jinzhan
The Yellow River basin is of critical strategic importance to China's economic and social development. The lower reaches are characterized by low flow rates and high sediment concentrations，exhibiting an uncoordinated water-sediment relationship.
Dongdong JIA, Meng CHEN, Kun LI, Xin ZHANG, Jun YANG, Songwei CHEN, Wenlong JIANG   +6 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

An Estimation Method of River Dry Runoff Alteration after Upper New Reservoirs Storage

Applied Sciences
The impact of reservoirs on downstream river hydrological characteristics is always a focal point in relevant studies exploring the relationship between rivers and dams. Anticipating river runoff patterns following the construction of new dams is crucial
Zuoqiang Chen, Ya Deng, Aixing Ma, Ying Hu, Jiashi Li, Lingqi Li   +5 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Assessing Differences in Groundwater Hydrology Dynamics Between In Situ Measurements and GRACE-Derived Estimates via Machine Learning: A Test Case of Consequences for Agroecological Relationships Within the Yazoo–Mississippi Delta (USA)

Hydrology
In situ groundwater monitoring is critical for irrigated agroecosystems and informs land cover changes. Yet, such data can pose management challenges and confound agroecological relationships.
Lucas J. Heintzman, Zahra Ghaffari, Abdel R. Awawdeh, Damien E. Barrett, Lance D. Yarbrough, Greg Easson, Matthew T. Moore, Martin A. Locke, Hakan I. Yasarer   +8 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Soil of the lower valley of the Dragonja river (Slovenia)

Acta Agriculturae Slovenica, 2015
Soil of the lower valley of the river Dragonja developed under specific soil-forming factors. Soil development in the area was influenced by alluvial sediments originating from surrounding hills, mostly of flysch sequence rocks, as a parent material, Sub-
Tomaž PRUS, Nina ZUPANČIČ, Helena GRČMAN   +2 more
doaj   +1 more source