Slow sedimentation and deformability of charged lipid vesicles [PDF]
The study of vesicles in suspension is important to understand the complicated dynamics exhibited by cells in vivo and in vitro. We developed a computer simulation based on the boundary-integral method to model the three dimensional gravity-driven ...
Gay, Guillaume+4 more
core +3 more sources
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan+2 more
wiley +1 more source
Coastal Sedimentation in a Tropical Barrier-Island System During the Past Century in Sepetiba Bay, Brazil [PDF]
The nature of sedimentation and sediment accumulation rates in Sepetiba Bay, Brazil were interpreted from grainsize patterns, natural radiochemical distributions and seismic stratigraphy.
Heloisa Vargas Borges+1 more
doaj +1 more source
ESTIMATION OF SOIL EROSION DYNAMICS USING REMOTE SENSING AND SWAT IN KOPAONIK NATIONAL PARK, SERBIA
Soil erosion is a global environmental and economic problem that is significantly related to land-use changes. Over the last decades, several mountain areas in Serbia were exposed to strong human pressure caused by winter tourism development. The largest
Ivan M. Potić+6 more
doaj +1 more source
Molar mass and solution conformation of branched alpha(1 - 4), alpha(1 - 6) Glucans. Part I: Glycogens in water [PDF]
Solution molar masses and conformations of glycogens from different sources (rabbit, oyster, mussel and bovine) were analysed using sedimentation velocity in the analytical ultracentrifuge, size-exclusion chromatography coupled to multi-angle laser light
Ang, S.+6 more
core +1 more source
The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson+7 more
wiley +1 more source
A new data on the geological structure, conditions of formation and faunal composition of the Early Cretaceous site of the terrestrial vertebrates by Shestakovo village (Kemerovo Region, Western Siberia) has been presented.The consolidated geological ...
A. V. Podlesnov+2 more
doaj +1 more source
Steady state sedimentation of ultrasoft colloids
The structural and dynamical properties of ultra-soft colloids - star polymers - exposed to a uniform external force field are analyzed applying the multiparticle collision dynamics approach, a hybrid coarse-grain mesoscale simulation approach, which ...
Gompper, Gerhard+2 more
core +1 more source
Sedimentation and subsidence history of the Lomonosov Ridge [PDF]
During the first scientific ocean drilling expedition to the Arctic Ocean (Arctic Coring Expedition [ACEX]; Integrated Ocean Drilling Program Expedition 302), four sites were drilled and cored atop the central part of the Lomonosov Ridge in the Arctic ...
Backman, J.+31 more
core +2 more sources
Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen+2 more
wiley +1 more source