Results 51 to 60 of about 175,945 (263)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Mass Balance of Cenozoic Andes-Amazon Source to Sink System—Marañón Basin, Peru

Geosciences, 2018
We investigate the mass balance of the Cenozoic Andes-Amazon source to sink system using rock uplift proxies and solid sedimentation of the Marañón Basin in Peru.
Gérôme Calvès, Ysabel Calderón, Christian Hurtado Enriquez, Stéphane Brusset, William Santini, Patrice Baby   +5 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

The Connection between a Suspended Sediments and Reservoir Siltation: Empirical Analysis in the Maziarnia Reservoir, Poland

Resources, 2020
This paper presents research on the influence of suspended sediments on selected aspects of a reservoir’s functioning. As the amount of sediment suspended in water (SS) there was found to correlate significantly with sedimentation rate (Us), it was
Maksymilian Cieśla, Renata Gruca-Rokosz, Lilianna Bartoszek   +2 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Rapid alternative methods for erythrocyte sedimentation rate measurement

Journal of Associated Medical Sciences, 2018
Backgrounds: Erythrocyte sedimentation rate (ESR) measurement is the most widely used in laboratory test to assess an inflammation or acute phase response. Objectives: To introduce two rapid alternative methods for ESR measurement.
Kunchit Kongros, Orathai Tangvarasittichai   +1 more
doaj  

Astronomically Forced Cyclicity and Cyclostratigraphic Framework of the Middle Jurassic Bath–Bajocian Formation in the West Siberian Basin

Applied Sciences
We aim to elucidate the sedimentary cyclicity of the Middle Jurassic Bath–Bajocian Formation in the northern S Oilfield of the West Siberian Basin, address the lack of high-resolution Milankovitch cycle research in this region, and support hydrocarbon ...
Chengyu Song, Yefei Chen, Lun Zhao, Yunyang Liu, Yujie Gao   +4 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source