Results 91 to 100 of about 155,966 (283)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

The improvement of breeding methods of middle-maturing hybrids of maize in Nizhnee Povolzhye

Зерновое хозяйство России, 2018
The article considers the results of the ecological trials (2008-2016) among the maize hybrids (FAO 200-249), developed in the different selection centers of Russia. The number of the hybrids (FAO 200-249) participating in the ecological trials was 36-43
V. I. Zhuzhukin, V. S. Gorbunov, S. A. Zaytsev, D. P. Volkov   +3 more
doaj   +2 more sources

Organization of plant breeding in the Czech Republic after the year 1948.

Kvasný průmysl, 2006
In 1948 plant breeding and seed growing companies in the CSR were nationalized. Changes in organization of plant breeding and seed growing marked the whole period of 1948-1989.
František RŮŽIČKA
doaj   +1 more source

A magyarországi máktermelésrÅ‘l [PDF]

Hazánkban az utóbbi években egyre nagyobb területeken folyik alkaloida és étkezési mák termelése. Megállapítható, hogy nem igazolódtak be azok a várakozások, melyek az uniós csatlakozástól a máktermelés csökkenését várták, annak ellenére,
Karacsony, Peter, Pal, Robert, Pinek, Gyula, Toth, Kalman   +3 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Experimental evaluation of organic substrates for germination testing of soybean seed [PDF]

Selekcija i Semenarstvo, 2020
High germination of seeds and seedling establishment are critical for soybean production since it determines crop density and eventually affects the yield.
Milivojević Marija, Branković-Radojčić Dragana, Vukadinović Radmila, Kojić Jasna, Dumanović Zoran, Petrović Tanja   +5 more
doaj  

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Object-oriented remote sensing image segmentation based on automatic multiseed region growing algorithm

工程科学学报, 2017
For the segmentation of a remote sensing image, the seeded region growing algorithm is a common method. The traditional single-seed region growing algorithm can only segment a remote sensing image in a single, continuous object with simple texture ...
YAN Dong-yang, MING Dong-ping
doaj   +1 more source