Results 131 to 140 of about 3,779,665 (404)

Antibacterial Activity of Psoralea corylifolia L. Seed and Aerial Parts with Various Extraction Methods [PDF]

, 2011
Sumitra Chanda, Mital Kaneria, Ratish Nair   +2 more
openalex   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Effects of various metal seed layers on the surface morphology and structural composition of the electroplated copper layer [PDF]

, 2009
Tae‐Gyu Woo, Il‐Song Park, Kyeong-Won Seol   +2 more
openalex   +1 more source

Dynamic DNA methylation reconfiguration during seed development and germination

Genome Biology, 2017
Unlike animals, plants can pause their life cycle as dormant seeds. In both plants and animals, DNA methylation is involved in the regulation of gene expression and genome integrity.
Taiji Kawakatsu, Joseph R. Nery, R. Castanon, J. Ecker   +3 more
semanticscholar   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Transcriptome analysis of the coexpression network of genes related to antioxidant characteristics after grain filling in purple rice

Scientific Reports
Antioxidant capacity is an important indicator for evaluating the growth and developmental quality of rice. This study has guiding significance for the cultivation of high-nutrient-value varieties.
Changhui Sun, Junkai Zhu, Ying Zhu, Jinxia Cao, Jiao Zhang, Yanqiong Zhang, Huijuan Zhou, Yangang Zhu, Yiming Ji, Rui Ding, Qiangqiang Xiong, Xiaobin Liu   +11 more
doaj   +1 more source

Proper seed storage (Liveseed Practice abstract) [PDF]

, 2020
What causes seed ageing? Seed ageing is caused by oxidation of the cell membranes, mitochondria, DNA, RNA and proteins in the seeds. This oxidation is stimulated by four factors: seed moisture level, temperature, oxygen and time.
Groot, Steven P.C.
core  

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Genome-wide association study of kernel colour traits and mining of elite alleles from the major loci in maize

BMC Plant Biology
Background Maize kernel colour is an important index for evaluating maize quality and value and mainly entails two natural pigments, carotenoids and anthocyanins.
Weiwei Chen, Fangqing Cui, Hang Zhu, Xiangbo Zhang, Siqi Lu, Chuanli Lu, Hailong Chang, Lina Fan, Huanzhang Lin, Junteng Fang, Yuxing An, Xuhui Li, Yongwen Qi   +12 more
doaj   +1 more source