Results 151 to 160 of about 2,153,562 (358)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

The Big BIT maize experiment: A large multi‐location, multi‐year, multi‐tester, multi‐population predictive breeding validation study

The Plant Genome
The Big Breeding Innovation Team (Big BIT) maize (Zea mays L.) experiment was one of the largest genomic data‐informed predictive breeding validation studies ever conducted.
Michael Jines, Michael Chandler, Dean Podlich, Andrew Baumgarten, Deanne Wright, Amy Jacobson, Honghua Zhao, Jared Gogerty, Matthew Regennitter, Hsiao‐Yi Hung, Riley McDowell, Tom Tang, Christine Diepenbrock, Hoda Helmi, Carlos Messina, Andrew Ross, Gary Henke, Lindsay Spangler, Matthew Caldwell, Leah Stirling, Andres Reyes, Carla Gho, Mark Cooper, John Arbuckle, Matthew Smalley, Sandra Milach, Geoff Graham, Liviu Radu Totir   +27 more
doaj   +1 more source

SEED HEALTH AND QUALITY STATUS OF MUSTARD SEED [PDF]

, 2009
A Thesis Submitted to the Faculty of Agriculture, Sher-e-Bangla Agricultural University, Dhaka in Partial fulfillment of the requirements for the degree of MASTER OF SCIENCE (MS) IN PLANT PATHOLOGYuality and health status of nine improved ...
GHOSH, PALASH
core  

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Reveal genomic insights into cotton domestication and improvement using gene level functional haplotype-based GWAS

Nature Communications
Genome-wide association studies (GWAS) are widely used to detect associations between genetic variants and phenotypes. However, few studies have thoroughly analyzed genes, the fundamental and most crucial functional units.
Guoan Qi, Yiqian Li, Wanying Zhang, Zegang Han, Jinwen Chen, Ziqian Zhang, Lisha Xuan, Rui Chen, Lei Fang, Yan Hu, Tianzhen Zhang   +10 more
doaj   +1 more source

The Seed Industry for Dryland Crops in Eastern Kenya

The development and promotion of improved crop varieties as well as efficient seed production, distribution, and marketing systems have contributed significantly to increased agricultural production and food security in Kenya. However, these impacts have
Njoroge, Kiarie, Muhammad, Lutta, Mwangi, Wilfred, De Groote, Hugo, Verkuijl, Hugo, Bett, Charles   +5 more
core  

From the seed... to the seed [PDF]

Winter school marathon, 2017
openaire   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source