Results 111 to 120 of about 2,610,066 (327)

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Seed priming improves endosperm weakening, germination, and subsequent seedling development of Solanum lycocarpum St. Hil.

, 2011
Seed priming is a treatment to improve seed quality and plant growth upon germination and is applied widely to crop species to improve uniformity and yield.
Matos, A. C.B., Toorop, P. E., Matos, A. C. B., Davide, A. C., Faria, J. M. Rocha, Silva, Edvaldo Aparecido Amaral da [UNESP][, Rocha Faria, J. M., Da Silva, E. A.A. [UNESP], Soares, G. C.M., Anese, S., Soares, G. C. M.   +10 more
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Manipulation of seed coat content for increasing oil content via modulating BnaMYB52 in Brassica napus

Cell Reports
Summary: Seed oil is synthesized in the embryo, which is surrounded by the seed coat. However, the genetic and molecular mechanisms of how seed coat development affects seed oil content (SOC) remains less studied.
Jiang Ye, Xiaowei Wu, Xiang Li, Yuting Zhang, Yuqing Li, Hui Zhang, Jie Chen, Yuyan Xiang, Yefan Xia, Hu Zhao, Zengdong Tan, Liang Guo, Xuan Yao   +12 more
doaj   +1 more source

MÉTODOS PARA SUPERAÇÃO DA DORMÊNCIA EM SEMENTES DE Garcinia gardneriana (Planch. & Triana) Zappi

Ciência Florestal, 2018
Garcinia gardneriana is a native tree species of the Atlantic Forest biome with commercial potential, industrial application, medicinal, ornamental and timber, which seeds have difficulties on germination.
Ana Patrícia Rocha, Valderez Pontes Matos, Lúcia Helena de Moura Sena, Mauro Vasconcelos Pacheco, Rinaldo Luiz Caraciolo Ferreira   +4 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Characterizing the Seed Coat in the Subtribe Angraecinae (Orchidaceae, Vandeae) and Its Taxonomic Value

The seeds of 121 species belonging to 38 genera of the subtribe Angraecinae (Orchidaceae) were studied in terms of their morphological characteristics under a scanning electron microscope (SEM). This study provided new data about the seed micromorphology
Roberto Gamarra, Guillermo Valdelvira, Álvaro Hernando, Ortúñez, Emma, De La Fuente, Pablo, Valdelvira, Guillermo, Hernando, Álvaro, Pablo De La Fuente, Emma Ortúñez, Gamarra, Roberto   +9 more
core   +1 more source

Antioxidant Capacity and Phytonutrient Content in the Seed Coat and Cotyledon of Common Beans (Phaseolus vulgaris L.) from Various Regions in Mexico

Antioxidants, 2018
The common bean is a good source of protein and bioactive substances giving it a large antioxidant capacity. The extensive variability of bean genotypes creates the need to characterize them with regard to their nutritional value as a tool in ...
Celia Chávez-Mendoza, K. I. Hernández-Figueroa, E. Sánchez   +2 more
semanticscholar   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

ARF-GAP-mediated interaction between the ER-Golgi v-SNAREs and the COPI coat [PDF]

, 2002
In eukaryotic cells, secretion is achieved by vesicular transport. Fusion of such vesicles with the correct target compartment relies on SNARE proteins on both vesicle (v-SNARE) and the target membranes (t-SNARE).
Rein, U., Rein, Ulrike, Anne Spang, Spang, Anne, Hans Dieter Schmitt, Andag, Uwe, Ulrike Rein, Duden, R., Schmitt, Hans Dieter, Duden, Rainer, Spang, A., Andag, U., Uwe Andag, Schmitt, H. D., Rainer Duden, Schmitt, H.   +15 more
core   +1 more source