Results 51 to 60 of about 10,285 (229)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Representation of Seed Coat Color of Azuki Bean by Using XYZ Color System
Japanese Journal of Crop Science, 2003 和菓子のあん原料に使われるアズキは, 見た目の色が食味とともに重要視されるため, 品質の重要な特性として種皮色の研究が行われてきた. 本研究では, 種皮色を色相, 明度および彩度で示すことができるXYZ表色系について検討した. 供試したエリモショウズの未熟から成熟までの種子および完熟した種子の種皮色には肉眼で著しい色の違いがみられた. 色相を表す主波長は539.8 (未成熟)∼616.0nm (完熟·濃色) に変異した. 完熟種子において, 明度を表すY値は17.01 (淡色)∼8.92 (濃色), 彩度を表す刺激純度は41.4 (淡色)∼19.8% (濃色) と濃色になるほど値が低下した.
NAGAOKA, Yasuyosi, SAWADA, Souhei
openaire +2 more sources
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells
FEBS Open Bio, EarlyView.RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour +2 more
wiley +1 more source
Plant Production Science, 2023 Azuki bean (Vigna angularis) is a small red bean commonly used in Japanese cuisine from ancient time. The most common azuki bean seed is red, but there are black, grey, brown, green, straw-colored, white, and various flecked varieties.
Norio Nagao +3 more
doaj +1 more source
INHERITANCE OF COTYLEDON, SEED-COAT, HILUM AND PUBESCENCE COLORS IN SOY-BEANS [PDF]
Genetics, 1921 Page 491, table 1, column 4, line 5, for "29" read "3." Page 491, table 1, column 6, line 5, for "23.39" read "2.42." Page 514, line 14, for (see PDF) Page 525, line 8, for volume "41" read volume "46." Page 525, line 11, for volume "46" read volume ...
openaire +3 more sources
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
FEBS Open Bio, EarlyView.HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source