Results 51 to 60 of about 10,228 (230)

Embryonal Control of Yellow Seed Coat Locus ECY1 Is Related to Alanine and Phenylalanine Metabolism in the Seed Embryo of Brassica napus

open access: yesG3: Genes, Genomes, Genetics, 2016
Seed coat color is determined by the type of pigment deposited in the seed coat cells. It is related to important agronomic traits of seeds such as seed dormancy, longevity, oil content, protein content and fiber content.
Fulin Wang   +7 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Representation of Seed Coat Color of Azuki Bean by Using XYZ Color System

open access: yesJapanese Journal of Crop Science, 2003
和菓子のあん原料に使われるアズキは, 見た目の色が食味とともに重要視されるため, 品質の重要な特性として種皮色の研究が行われてきた. 本研究では, 種皮色を色相, 明度および彩度で示すことができるXYZ表色系について検討した. 供試したエリモショウズの未熟から成熟までの種子および完熟した種子の種皮色には肉眼で著しい色の違いがみられた. 色相を表す主波長は539.8 (未成熟)∼616.0nm (完熟·濃色) に変異した. 完熟種子において, 明度を表すY値は17.01 (淡色)∼8.92 (濃色), 彩度を表す刺激純度は41.4 (淡色)∼19.8% (濃色) と濃色になるほど値が低下した.
NAGAOKA, Yasuyosi, SAWADA, Souhei
openaire   +2 more sources

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Variation in antioxidant capacity of the seven azuki bean (Vigna angularis) varieties with different seed coat color

open access: yesPlant Production Science, 2023
Azuki bean (Vigna angularis) is a small red bean commonly used in Japanese cuisine from ancient time. The most common azuki bean seed is red, but there are black, grey, brown, green, straw-colored, white, and various flecked varieties.
Norio Nagao   +3 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

Seed coat color, weight and eye pattern inheritance in gamma-rays induced cowpea M2-mutant line

open access: yesJournal of Genetic Engineering and Biotechnology, 2016
Gamma radiation is a very effective tool for inducing genetic variation in characters of many plants. Black seeds of M2 mutant were obtained after exposure of an Egyptian cowpea cultivar (Kaha 1) to a low dose of gamma rays.
Reda M. Gaafar   +2 more
doaj   +1 more source

Effect of Heat Treatment on Nutritional and Chromatic Properties of Mung Bean (Vigna radiata L.)

open access: yesAgronomy, 2022
Chlorophyll is the primary source of color in widespread green plants. It has been investigated in mung bean seed coats and cotyledons. This study aimed to examine chromatic changes in mung beans during heat processing.
Ping-Hsiu Huang   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Home - About - Disclaimer - Privacy