Results 41 to 50 of about 31,699 (258)
Effect of Pansy (Viola x wittrockiana gams) Seeds Colour and Size on their Germination
Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 2008 Four commercial seed lots from the Polish seed companies of pansy (Viola x wittrockiana Gams) with low germination capacity were sorted into 2 size fractions: small and large: below 4 mm long and above 4 mm and 3 colour fractions: yellow, brown and dark,
Rosinska AGNIESZKA, Roman HOLUBOWICZ
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Optimum harvest maturity for Leymus chinensis seed
Biology Open, 2016 Timely harvest is critical to achieve maximum seed viability and vigour in agricultural production. However, little information exists concerning how to reap the best quality seeds of Leymus chinensis, which is the dominant and most promising grass ...
Jixiang Lin +6 more
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Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Effect of physical mutagen on expression of characters in arid legume pulse cowpea (Vigna unguiculata (L.) Walp.) [PDF]
Electronic Journal of Plant Breeding, 2010 Studies on physical induced mutagenesis, gamma rays were performed by exposing the healthy and dry seeds of cowpeavariety CO 4 to gamma rays 20, 30, 40, 50, 60 and 70 kR.
V.Ashok kumar, R.Usha kumari, N.Vairam and R.Amutha
doaj
An Analysis of Seed Colour During Ripening of Cabernet Sauvignon Grapes
South African Journal of Enology & Viticulture, 2017 This case study examines seed colour during ripening using an exhaustive colorimetric analysis. The aim was to associate the chemical ripening with the seed colour in order to estimate the ripening stages of Cabernet Sauvignon grapes. Cluster samples, obtained from a vertical shoot-positioned vineyard in central Chile, were monitored for their ...
Fredes, C. +2 more
openaire +3 more sources