Results 101 to 110 of about 3,277,284 (304)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Seeding Density Outweighs Light Intensity in Microgreens Yield on a Vertical Farming System
HorticulturaeThe optimal photosynthetic photon flux density (PPFD) and seeding density (SD) combinations for microgreens production on vertical farming systems remain unclear for many species.
Felipe Marques de Lima +8 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
QTL analysis and candidate gene prediction for seed density per silique by QTL-seq and RNA-seq in spring Brassica napus L. [PDF]
PLoS One, 2023 Xing X +6 more
europepmc +1 more source
Factors affecting the density of Brassica napus seeds
Seed Science and Technology, 2006 Brassica napus seed is composed of low density oil (0.92 g.cm(-3)) and higher density solids (1.3-1.45 g.cm(-3)). Seed buoyant density may potentially be used to determine seed oil content and to separate seeds with different oil contents, however, we have found that seeds with the lowest buoyant density had lower than expected oil contents.
Young, L. +3 more
openaire +2 more sources
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
IMPACT OF RAPE SEED DENSITY ON PRODUCTION PROFITABILITY
Annals of the Polish Association of Agricultural and Agribusiness Economists, 2017 The aim of the study was to compare the profitability of winter oilseed rape with two sowing methods: (row sowing – seed density 60 seeds per 1 m2 and spot sowing – seed density 40 seeds per 1 m2). The yield of rape seed was varied and was at the point sowing – 4.43 t/ha and row sowing – 5.24 t/ha.
Marek Gugała +4 more
openaire +2 more sources
Frugivory and seed dispersal by carnivores in the Rhodopi mountains of northern Greece [PDF]
, 1997 The frugivory and seed dispersal by carnivores were studied using a combination of vegetation surveys, fruit production counts and analysis of faeces distribution and content.
Giannakos, Panayiotis
core
Potential of the electrical conductivity of seed soak water and early counts of radicle emergence to assess seed quality in some native species [PDF]
, 2018 The research leading to these results has received funding from the People Programme (Marie Curie Actions) of the European Union’s Seventh Framework Programme FP7/2007- 2013/ under REA grant agreement n°607785 (NASSTEC).
Powell, Alison Anne +7 more
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source