Results 111 to 120 of about 3,277,284 (304)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Effect of seed density and planting depth on quantitative characteristics of Cedrus deodara seedling [PDF]

تحقیقات جنگل و صنوبر ایران, 2007
This investigation was carried out in spilt plot design with three replication and two treatments (depth of planting and seed density) in Pasand research station in North of Iran, Mazandaran province.
Sayfollah Khorenkeh, Sa'eid Pournajaf, Kambiz Espahbodi, Abdorreza Dehbandi   +3 more
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The dynamic of the controversy around the brussel pedestrian

, 2017
La dynamique de la controverse apparue autour du projet de piétonisation des boulevards centraux de la Ville de Bruxelles est relue à travers la théorie de l’acteur réseau (Callon &Latour 1986) .
Charlery de la Masselière, Madeleine, Stassart, Pierre M, Van Haute, Stéphane, Esnoul, Elise, Pfohl, Clémentine, Gérard, Marie   +5 more
core  

Assessing the Genotypic Differences for Seed Set and Seed Abortion in Tomato Genotypes [PDF]

, 2009
Tomato (_Lycopersicon esculentum_ Mill.) is one of the most popular fruit vegetable around the world. Seed abortion where in only a small proportion of ovules in an ovary develops into matured seeds, is a wide spread phenomenon in multi-ovulated species.
Ganeshaiah Narayana, Uma Shaanker, Chalapathy K. Reddy   +2 more
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Ecophysiologic Indices of Wheat as Influenced by Plant Density and Application of Herbicide [PDF]

Ikufīziyuluzhī-i Giyāhān-i Zirā̒ī, 2017
To evaluate the effects of application of herbicides and different plant densities on seed yield, weed density and chlorophyll content in wheat (cv. Bahar), a split plot experiment based on randomized complete blocks design with three replications was ...
Ehsanollah Zeidali, Rahim Naseri, Amir Mirzaei, Ali Asghar Chit Band   +3 more
doaj  

Seeding Density Directly Influences Crambe Productivity

Revista de Gestão Social e Ambiental
Objective: The objective of this study was to evaluate the development and production characteristics of crambe, under different planting densities and different spacing between rows.   Theoretical Framework: For crops that are still little explored, such as crambe, sowing management in new regions lacks information that would enable rural producers to
Lucas Marquezan Nascimento, Eduardo Pradi Vendruscolo, Fernando Ribeiro Teles de Camargo, Marcos Coelho, Fernanda Espíndola Assumpção Bastos, Tassila Aparecida do Nascimento de Araújo   +5 more
openaire   +1 more source