Results 61 to 70 of about 5,322,660 (343)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

The Fourier Space Statistics of Seedlike Cosmological Perturbations

, 1993
We propose a new test for distinguishing observationally cosmological models based on seed-like primordial perturbations (like cosmic strings or textures), from models based on Gaussian fluctuations.
Perivolaropoulos, Leandros
core   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Demographic Processes Allow Echinochloa crus-galli to Compensate Seed Losses by Seed Predation

Agronomy, 2021
The effect of weed management that targets the seed stage on subsequent life stages is largely unknown. Post-dispersal seed predation reduces the number of seeds from the soil surface before the seeds contribute to the seedbank.
Heike Pannwitt, Paula R. Westerman, Friederike De Mol, Bärbel Gerowitt   +3 more
doaj   +1 more source

Seed rain and soil seed banks limit native regeneration within urban forest restoration plantings in Hamilton City, New Zealand [PDF]

, 2012
Restoration of native forest vegetation in urban environments may be limited due to isolation from native seed sources and to the prevalence of exotic plant species.
Clarkson, Bruce D., Overdyck, Elizabeth
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Seed Rate and Row Spacing Effects on Yield and Quality of Sorghum Maturity Groups Under Central European Conditions

Seeds
Efficient and climate-resilient Sorghum bicolor L. cultivation is increasingly important under Central European conditions. This study evaluated two hybrids across two locations in 2023–2024 with row spacings of 25, 45, and 75 cm and four sowing ...
Balázs Szemerits, Gábor Kukorelli, Wogene Solomon Kabato, Zoltán Molnár   +3 more
doaj   +1 more source

Levels of Germinable Seed in Topsoil and Yak Dung on an Alpine Meadow on the North-East Qinghai-Tibetan Plateau

Journal of Integrative Agriculture, 2013
In order to clarify the interactive mechanism between grazing yak and alpine meadow on the Qinghai-Tibetan Plateau, our study assessed seed density (by species) in the topsoil of alpine meadow with different grazing intensities in the Tianzhu area, north-
Xiao-jun YU, Chang-lin XU, Fang WANG, Zhan-huan SHANG, Rui-jun LONG   +4 more
doaj   +1 more source

Cosmic Electromagnetic Fields due to Perturbations in the Gravitational Field [PDF]

, 2012
We use non-linear gauge-invariant perturbation theory to study the interaction of an inflation produced seed magnetic field with density and gravitational wave perturbations in an almost Friedmann-Lema\^itre-Robertson-Walker (FLRW) spacetime.
Bishop Mongwane, Bob Osano, C. W. Misner, E. R. Harrison, G. F. Ellis, Peter K. S. Dunsby   +5 more
core   +2 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source