Results 101 to 110 of about 30,634 (331)

Diallyl Trisulfide From Garlic Regulates RAB18 Phase Separation to Inhibit Lipophagy and Induce Cuproptosis in Hepatic Stellate Cells for Antifibrotic Effects

Advanced Science, EarlyView.
Diallyl trisulfides (DATs) selectively induce cuproptosis in hepatic stellate cells (HSCs) by targeting Ras‐related protein Rab‐18 (RAB18) and regulating lipophagy. DATs promote RAB18 phase separation, enhance mitochondrial‐associated membrane structures (MAMs) formation, and increase succinylation of dihydrolipoamide dehydrogenase (DLD) at K320.
Haoyuan Tian, Shujiang Sun, Xinran Qiu, Junrui Wang, Yuanyuan Gao, Jianmei Chen, Xiang Han, Zhengyang Bao, Xiaohan Guo, Yuqi Sun, Yuxin Lin, Mengru Hu, Feng Zhang, Zili Zhang, Feixia Wang, Shizhong Zheng, Jiangjuan Shao   +16 more
wiley   +1 more source

Genealogy of a Wright Fisher model with strong seed bank component [PDF]

arXiv, 2014
We investigate the behaviour of the genealogy of a Wright-Fisher population model under the influence of a strong seed-bank effect. More precisely, we consider a simple seed-bank age distribution with two atoms, leading to either classical or long genealogical jumps (the latter modeling the effect of seed-dormancy).
arxiv  

Chromosome‐Level Genome Assembly of the Leafcutter Bee Megachile rotundata Reveals Its Ecological Adaptation and Pollination Biology

Advanced Science, EarlyView.
The genome of Megachile rotundata, an extensively managed solitary pollination bee species, has been sequenced, covering 280.68 Mb and predicting 10 701 genes. The study reveals significant expansions of the Toll gene family and their abundant expression in diapause prepupae, highlighting enhanced immune responses during diapause. This genome serves as
Rangjun Shi, Pan Duan, Mengmeng Zhu, Rong Zhang, Zihua Zhao, Xin Nie, Hanhou He, Li Hou, Xianhui Wang   +8 more
wiley   +1 more source

Danshensu attenuated lipopolysaccharide‐induced LX‐2 and T6 cells activation through regulation of ferroptosis

Food Science &Nutrition, Volume 11, Issue 1, Page 344-349, January 2023., 2023
Danshensu (Dan) attenuates lipopolysaccharide‐induced hepatic stellate cells activation via decreasing expression of collagen І, connective tissue growth factor, glutathione peroxidase 4, cystine/glutamate antiporter xCT, and lipocalin‐2. However, Dan increases lipid reactive oxygen species accumulation.
Changting Wang, Zhiming Su, Jian‐Hua Xu, Chih‐Yuan Ko   +3 more
wiley   +1 more source

Novel Electroactive Therapeutic Platforms for Cardiac Arrhythmia Management

Advanced Science, EarlyView.
Electroactive platforms offer promising applications in cardiac arrhythmia. Based on their energy sources and mechanisms, electroactive platforms are categorized into i) direct electrical stimulation, ii) self‐powered electroactive systems, iii) physical stimuli‐mediated electroactive systems, and iv) conductive systems, and their applications in ...
Juwei Yang, Longfei Li, Yiran Hu, Zhou Li, Wei Hua   +4 more
wiley   +1 more source

Selection of the promising accessions of jamun (Syzygium cumini (L.) skeels) based on pomological characterizations

Food Science &Nutrition, Volume 11, Issue 1, Page 470-480, January 2023., 2023
The obtained results are useful for designing conservation strategies for the germplasm as well as implementing breeding programs such as introducing cultivars with different goals such as early or late ripening and seedless, non‐astringent, large, and deeper color‐fruits.
Ali Khadivi, Farhad Mirheidari, Abdolvahid Saeidifar, Younes Moradi   +3 more
wiley   +1 more source

A Bio‐Adaptive Janus‐Adhesive Dressing with Dynamic Lubrication Overlayer for Prevention of Postoperative Infection and Adhesion

Advanced Science, EarlyView.
Slippery‐adhesive Janus gel dressing exhibits both stable tissue adhesive and outstanding efficiency in repelling physiological fluids. As a physical barrier, a liquid‐infused surface with a dynamic lubrication overlayer possesses excellent antibiofouling properties, making it highly effective in preventing bacterial infections and postoperative tissue
Yuan Gao, Junchang Guo, Shuangyang Li, Liansong Ye, Binyang Lu, Jiaxin Liu, Jing Luo, Yijia Zhu, Liuxiang Chen, Tingfa Peng, Jinlong Yang, Dehui Wang, Chaoming Xie, Xu Deng, Bing Hu   +14 more
wiley   +1 more source

Somatic mutations reveal complex metastatic seeding from multifocal primary prostate cancer

International Journal of Cancer, Volume 152, Issue 5, Page 945-951, 1 March 2023., 2023
What's new? Intrapatient tumor heterogeneity and clonal evolution of primary tumor foci into metastatic disease remain significant challenges for prostate cancer treatment. Here, investigating metastatic lesion origins, the authors compared somatic mutations in spatially distinct primary foci to mutations in recurring disease in seven prostate cancer ...
Kristina T. Carm, Bjarne Johannessen, Mari Bogaard, Anne Cathrine Bakken, Aase V. Maltau, Andreas M. Hoff, Ulrika Axcrona, Karol Axcrona, Ragnhild A. Lothe, Rolf I. Skotheim   +9 more
wiley   +1 more source

IL‐33‐Induced TREM2+ Macrophages Promote Pathological New Bone Formation Through CREG1‐IGF2R Axis in Ankylosing Spondylitis

Advanced Science, EarlyView.
This study identifies TREM2+ macrophages as key contributors to pathological bone formation in ankylosing spondylitis (AS). These macrophages mediate pathological new bone formation via the CREG1‐IGF2R‐PI3K‐AKT pathway and are regulated by IL‐33 through STAT6 phosphorylation.
Wenjun Hao, Siwen Chen, Hua Chao, Zihao Li, Hao Yang, Dongying Chen, Sifang Li, Shuai Zhang, Jingyu Zhang, Jianru Wang, Zemin Li, Xiang Li, Zhongping Zhan, Tangming Guan, Yiwen Zhang, Wende Li, Hui Liu   +16 more
wiley   +1 more source

Differential incidence of the lemma on seed germination among different Paspalum dilatatum genotypes

Journal of Seed Science
: Paspalum dilatatum Poir. is a promising perennial summer grass forage for temperate regions, but among other factors, slow stand establishment has hindered its adoption. One of the reasons may be seed dormancy.
Nicolás Glison, Luis Viega, Pablo Speranza   +2 more
doaj   +1 more source