Results 111 to 120 of about 23,256 (307)

Seed Regeneration in Taxus baccata: Unveiling Ecological Restrictions and Paving the Way for Future Studies

open access: yesEcology and Evolution
Taxus baccata, commonly known as English yew, is an evergreen tree native to regions ranging from Ireland and Sweden to Morocco, Algeria, and northern Iran.
Keyvan Maleki   +5 more
doaj   +1 more source

Discovery of a Potent and Selective TEAD Degrader with Durable Degradation Activity

open access: yesAdvanced Science, EarlyView.
KG‐FP‐003, a highly potent TEAD‐YAP PROTAC derived from the patented inhibitor is developed. It selectively degrades endogenous TEAD proteins in HiBiT systems without IMiD‐related off‐target effects. Screening across 867 cancer cell lines revealed broad and superior anti‐tumor activity, highlighting its therapeutic potential through targeted TEAD ...
Linhui Cao   +25 more
wiley   +1 more source

Adamts1 Exacerbates Post‐Myocardial Infarction Scar Formation via Mechanosensing of Integrin α8

open access: yesAdvanced Science, EarlyView.
Proposed mechanistic model of ADAMTS1‐ITGα8 mechanotransduction in post‐MI scar formation. Schematic illustration showing the mechanistic pathway by which endothelial cell (EC) derived Adamts1 regulates cardiac fibroblast activation through ITGα8‐mediated mechanotransduction following myocardial infarction (MI).
Chun‐Yan Kong   +11 more
wiley   +1 more source

Natural variations in a barley aldehyde oxidase 1 gene affect seed germination and malting quality

open access: yesCrop Journal
Multiple phytohormones, including gibberellin (GA), abscisic acid (ABA), and indole-3-acetic acid (IAA), regulate seed germination. In this study, a barley aldehyde oxidase 1 (HvAO1) gene was identified, which is located near the SD2 (seed dormancy 2 ...
Le Xu   +7 more
doaj   +1 more source

AGAPIR: A Novel PIWI‐Interacting RNA Enhancing Post‐Decompression Angiogenesis in Degenerative Cervical Myelopathy

open access: yesAdvanced Science, EarlyView.
The restoration of blood flow following surgical decompression for degenerative cervical myelopathy (DCM) significantly contributes to the amelioration of neurological deficits. This study identifies AGAPIR, an angiogenesis‐associated PIWI‐interacting RNA, enhances angiogenesis and motor function recovery post‐spinal cord decompression in a mouse model
Yongheng Xie   +8 more
wiley   +1 more source

The Study of Seed Dormancy and Viability in Rice [PDF]

open access: hybrid, 1967
S SIVASUBRAMANIAM   +2 more
openalex   +1 more source

Snord15b Maintains Stemness of Intestinal Stem Cells via Enhancement of Alternative Splicing of Btrc Short Isoform for Suppression of β‐Catenin Ubiquitination

open access: yesAdvanced Science, EarlyView.
In intestinal stem cells (ISCs), Snord15b associates with Ilf2 to recruit splicing factors for alternative splicing of Btrc mRNA, leading to the generation of short Btrc. This short Btrc fails to form a functional E3 ubiquitin ligase complex for β‐catenin ubiquitination and degradation.
Yuwei Xu   +13 more
wiley   +1 more source

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