Results 111 to 120 of about 74,337 (349)

DCAF13 Safeguards Hematopoietic Stem Cells via RRS1‐Regulated Ribosome Biogenesis

open access: yesAdvanced Science, EarlyView.
This study establishes DCAF13 as an essential regulator for hematopoietic stem cell (HSC) function. Its deletion in mice causes lethal pancytopenia and HSC depletion. Mechanistically, DCAF13 interacts with RRS1 and mediates its non‐degradative K27‐linked ubiquitination, thereby stabilizing RRS1 to maintain ribosome biogenesis and protein translation ...
Mengke Li   +25 more
wiley   +1 more source

Effect of Seed Dormancy Breaking Treatments on Germination and α-amylase Enzyme Activity in Seeds of Three Ecotypes of Astragalus (Astragalus cyclophyllu)

open access: yesپژوهش‌های بذر ایران, 2020
DOR: 98.1000/2383-1251.1398. 6.15.12.2.1575.41 Extended Abstract  Introduction: Seed dormancy, as a technique to avoid environmental stress, is important in preserving plant species and could be of various types including physiological, physical ...
Akram Rostamipoor   +2 more
doaj  

TGF-β2 dictates disseminated tumour cell fate in target organs through TGF-β-RIII and p38α/β signalling [PDF]

open access: yes, 2013
In patients, non-proliferative disseminated tumour cells (DTCs) can persist in the bone marrow (BM) while other organs (such as lung) present growing metastasis.
Aguirre Ghiso, Julio A.   +7 more
core   +2 more sources

A Natural Sweetener‐inducible Genetic Switch Controls Therapeutic Protein Expression in Mammals

open access: yesAdvanced Science, EarlyView.
This study develops a natural sweetener, the psicose‐inducible transgene expression (PURE) system based on an Agrobacterium tumefaciens–derived transcriptional repressor PsiR. The PURE system is highly specific to psicose, being insensitive to other sugars and structurally similar molecules.
Longliang Qiao   +16 more
wiley   +1 more source

Notes on the germination of the endangered species Sclerolaena napiformis (Chenopodiaceae) [PDF]

open access: yes, 2013
Sclerolaena napiformis is found on fertile plains in northern Victoria and southern New South Wales and is endangered Australia-wide. Introductory work on its germination shows that seeds cannot germinate until the woody fruit has broken down.
Carta, Francesca E., Parsons, R. F.
core  

Decoding the Integrated Stress Response of Pancreatic Cancer: Identifying a Serine‐dependent Tumor Subset Under Metabolic Relationships With CAFs.

open access: yesAdvanced Science, EarlyView.
Researchers identified a pancreatic cancer subset with low global protein synthesis but heightened translation of stress‐response genes like ATF4, rendering cells resistant to chemotherapy and apoptosis. These tumors depend on serine and cysteine from surrounding cancer‐associated fibroblasts (CAFs), which shift to produce serine by curbing collagen ...
Sauyeun Shin   +25 more
wiley   +1 more source

Heat shock effect in breaking physical dormancy in seeds of Lupinus elegans and L. rotundiflorus from Jalisco, Mexico [PDF]

open access: gold, 2014
Erika Robles-Díaz   +4 more
openalex   +1 more source

VE‐Cadherin–Actin Regulation Promotes Mechanotransduction and Monolayer Maturation Involving a Tension‐Sensitive Intermediate State

open access: yesAdvanced Science, EarlyView.
This study investigates how endothelial monolayers balance cohesion and plasticity during mechanical stimulation. In HUVECs, shear stress induces a tension‐sensitive intermediate state in which junctional VE‐cadherin and actomyosin relaxation levels coordinate actin/integrin remodeling. This rapid, reversible state strengthens cell junctions, preserves
Jonas Franz   +11 more
wiley   +1 more source

Home - About - Disclaimer - Privacy