Results 41 to 50 of about 268,651 (265)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

The implementation of new standards for Allium aflatunense flowering onion

Овощи России, 2009
Allium aflatunense has been studied at All-Russian Research Institute of Vegetable Breeding and Seed Production as a new plant culture that has high adaptability, acceptable qualities so that it can be well introduced to breeding program for middle belt ...
L.V. Pavlov, O.T. Paraskova, A.F. Agafonov, M.V. Dubova   +3 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Environmental suitability of VNIISSOK's area for vegetable marrow breeding program for adaptability and productivity

Овощи России, 2009
The significant variation has been shown in parameters of VNIISSOK's environmental area that have been tested for the several last years. This can be used for breeding program in vegetable marrow for plant adaptability.
H.G. Dobrutskaya, M.C. Antoshkina, V.P. Kushnereva, G.A. Khimich   +3 more
doaj   +1 more source

Seed Production

, 1898
(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
openaire   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

RESULTS OF POLYMORPHISM STUDIES OF POPULATION OF WHITE HEAD CABBAGE CV. AMAGER 611

Овощи России, 2012
The results of complex estimation of structure of variety population Amager 611, the genetic analysis by inbreeding (J1-J9) and RAPD-markers are shown. The role of 17 phenotype groups in the variety population was determined.
E. G. Dobrutskaya, E. G. Baranova, V. I. Orlova, V. I. Startsev, L. L. Bondareva   +4 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

URGENT PROBLEMS SOLVING OF VEGETABLE BREEDING ACCORDING TO THE IDEAS OF N.I. VAVILOV (based on the III-rd International Scientific-Practical Conference «Modern trends in plant breeding and seed production of vegetable crops. Traditions and Prospects», VNIISSOK, 2012)

Овощи России, 2012
November 25, 2012 the international scientific community of geneticists and plant breeders will be celebrating the 125thanniversary of the birth of botanist and genetics, agronomist, geographer and founder of the national school of biology and breeding ...
V. F. Pivovarov, O. N. Pishnaya, S. M. Sirota, L. K. Gurkina, M. M. Tareeva, T. S. Naumenko   +5 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source