Results 51 to 60 of about 267,132 (267)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Овощи России, 2009 The significant variation has been shown in parameters of VNIISSOK's environmental area that have been tested for the several last years. This can be used for breeding program in vegetable marrow for plant adaptability.
H.G. Dobrutskaya +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Овощи России, 2012 November 25, 2012 the international scientific community of geneticists and plant breeders will be celebrating the 125thanniversary of the birth of botanist and genetics, agronomist, geographer and founder of the national school of biology and breeding ...
V. F. Pivovarov +5 more
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Perennial onion is a plant of nourishing and medicinal properties
Овощи России, 2009 Vegetables are a source of vitamins, salts, acids, carbohydrates and biologically active substances which are necessary for human's vital function. Academician Pavlov I.V.
A. F. Agafonov +2 more
doaj +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
CANNING GREEN PEA VARIETIES OF VNIISSOK BREEDING
Овощи России, 2012 The conveyor of production of canning green pea varieties of VNIISSOK breeding is represented.
I. P. Kotlyar +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
FEATURES OF PUMPKIN AND SQUASH GROWING FOR MECHANICAL SEPARATION OF SEEDS
Овощи России, 2012 The features of growing of pumpkin and squash for seed production in the conditions of the Moscow region are shown. The size-weight characteristics of grown fruits and seeds of pumpkin crops in order to use these indicators in machine seeds selection are
L. V. Pavlov +3 more
doaj +1 more source