Results 61 to 70 of about 268,651 (265)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

IRRECIPROCAL INTERJCULTIVAR SELFJINCOMPATIBILITY OF SOME SAMPLES OF SWEET PEPPER (CAPSICUM ANNUUM L.)

Овощи России, 2015
The irreciprocal self'incompatibility at site'specific hybridization of Capsicum annuum L. and its morphological features in the varieties of sweet pepper Belosnezhka and Karlik during pollination by other samples is described.
O. A. Blandinskaya, E. G. Kozar, L. B. Bespalko, I. T. Balashova   +3 more
doaj   +1 more source

SEED YAM PRODUCTION WITH MINITUBERS

Nigeria Agricultural Journal, 2004
The performance of various sizes of minitubers of both D. alata (UM680) and D. rotundata (Obioturugo and Abi) were evaluated for size and yield of seed yams between 1998 and 2000. Minitubers are whole but small (30-100g) tubers that farmers could simply plant directly into their farms, as is the case for seed potatoes. D.
IKEORGU, J.E.G., IGBOKWE, M.C.
openaire   +3 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

GENETICS AND BREEDING OF PEPPER AND EGGPLANT (CONFERENCE MATERIALS «XV MEETING ON GENETICS AND BREEDING OF CAPSICUM AND EGGPLANT», EUCARPIA, TORINO, ITALY, 2J4 SEPTEMBER 2013)

Овощи России, 2015
On 2-4th of September, 2013 the International «XV EUCARPIA Meeting on Genetics and Breeding of Capsicum and Eggplant» was held in Torino (Italy). The problems of utilization of genetic resources, evaluation and release of breeding material were discussed.
T. P. Suprunova, D. V. Shumilina, O. N. Pishnaya, M. I. Mamedov   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Molecular and physiological indicators of heat tolerance in upland cotton (Gossypium hirsutum L.)

Journal of Plant Interactions
Heat stress is a major abiotic constraint limiting cotton (Gossypium hirsutum L.) productivity under climate change. This study evaluated the integrated molecular and physiological responses of fifteen upland cotton cultivars exposed to acute heat stress
Abrorjon Y. Kurbonov, Mohigul Abdullayeva, Feruza F. Mamedova, Muxammad-Latif M. Nazirov, Naima Sh. Khojaqulova, Sanjar Sh. Djumaev, Yashin Babayev, Sayfulla Boboyev   +7 more
doaj   +1 more source

DISEASE RESISTANCE OF WHITE HEAD CABBAGE VARIETIES AS A FACTOR OF REDUCTION OF THE PEST RISKS IN VEGETABLE GROWING

Овощи России, 2015
The resistance of the released varieties of white head cabbage to pests and diseases in the Moscow region (2006 2012 years) has been studied. The diseases and pests as well as their extension and degree of infestation of cabbage plants were recorded.
A. A. Maslova, A. A. Ushakov, V. I. Startsev, L. L. Bondareva   +3 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

TYPES OF FASCIATION IN PLANTS AND FACTORS AFFECTING ITS MANIFESTATION

Овощи России, 2012
The review deals with the phenomenon of fasciation and its types, as well as factors that contribute to its occurrence.
S. N. Mayorov, A. V. Molchanova, L. L. Bondareva, V. I. Startsev   +3 more
doaj   +1 more source