Results 61 to 70 of about 267,132 (267)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

IRRECIPROCAL INTERJCULTIVAR SELFJINCOMPATIBILITY OF SOME SAMPLES OF SWEET PEPPER (CAPSICUM ANNUUM L.)

Овощи России, 2015
The irreciprocal self'incompatibility at site'specific hybridization of Capsicum annuum L. and its morphological features in the varieties of sweet pepper Belosnezhka and Karlik during pollination by other samples is described.
O. A. Blandinskaya, E. G. Kozar, L. B. Bespalko, I. T. Balashova   +3 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

GENETICS AND BREEDING OF PEPPER AND EGGPLANT (CONFERENCE MATERIALS «XV MEETING ON GENETICS AND BREEDING OF CAPSICUM AND EGGPLANT», EUCARPIA, TORINO, ITALY, 2J4 SEPTEMBER 2013)

Овощи России, 2015
On 2-4th of September, 2013 the International «XV EUCARPIA Meeting on Genetics and Breeding of Capsicum and Eggplant» was held in Torino (Italy). The problems of utilization of genetic resources, evaluation and release of breeding material were discussed.
T. P. Suprunova, D. V. Shumilina, O. N. Pishnaya, M. I. Mamedov   +3 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Molecular and physiological indicators of heat tolerance in upland cotton (Gossypium hirsutum L.)

Journal of Plant Interactions
Heat stress is a major abiotic constraint limiting cotton (Gossypium hirsutum L.) productivity under climate change. This study evaluated the integrated molecular and physiological responses of fifteen upland cotton cultivars exposed to acute heat stress
Abrorjon Y. Kurbonov, Mohigul Abdullayeva, Feruza F. Mamedova, Muxammad-Latif M. Nazirov, Naima Sh. Khojaqulova, Sanjar Sh. Djumaev, Yashin Babayev, Sayfulla Boboyev   +7 more
doaj   +1 more source

TYPES OF FASCIATION IN PLANTS AND FACTORS AFFECTING ITS MANIFESTATION

Овощи России, 2012
The review deals with the phenomenon of fasciation and its types, as well as factors that contribute to its occurrence.
S. N. Mayorov, A. V. Molchanova, L. L. Bondareva, V. I. Startsev   +3 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

PHENOLIC COMPOUNDS CONTENT IN FRUITS OF DIFFERENT EGGPLANT SPECIES: S. MELONGENA L., S. AETHIOPICUM L. AND S. MACROCARPON L. - IN THE TEMPERATE CLIMATE

Овощи России, 2017
In the genus Solanum there are a number of less common vegetables. S. aethiopicum L. and S. macrocarpon L. are a two popular species of eggplant, traditionally grown in tropical Africa.
M. I. Mamedov, O. N. Pishnaya, Y. A. Dzhos, V. M. Verba, A. A. Matyukina   +4 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source