Results 71 to 80 of about 268,651 (265)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

PHENOLIC COMPOUNDS CONTENT IN FRUITS OF DIFFERENT EGGPLANT SPECIES: S. MELONGENA L., S. AETHIOPICUM L. AND S. MACROCARPON L. - IN THE TEMPERATE CLIMATE

Овощи России, 2017
In the genus Solanum there are a number of less common vegetables. S. aethiopicum L. and S. macrocarpon L. are a two popular species of eggplant, traditionally grown in tropical Africa.
M. I. Mamedov, O. N. Pishnaya, Y. A. Dzhos, V. M. Verba, A. A. Matyukina   +4 more
doaj   +1 more source

A seed dresser's perspective of seed production

Proceedings of the New Zealand Grassland Association, 1990
The objective is to optimise financial return to the seed grower by saving the maximum amount of seed at the highest possible quality standards. It is possible to always achieve the highest grades by dressing* a line very hard and discarding a large proportion of the sample, with a loss of potential value to the grower.
openaire   +2 more sources

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

MONITORING OF VIRAL INFECTION IN SWEET PEPPER PLANTS GROWN IN GREENHOUSE AND OPEN FIELD IN DIFFERENT CLIMATIC ZONES

Овощи России, 2017
35 viruses have been reported to infect peppers (Capsicum spp.) and those lead to economic losses like low  and  variable yield. Viral diseases are an important factor  provoking  low  yield and reduced  fruit  quality.
M. I. Mamedov, O. N. Pishnaya, E. A. Dzhos, I. A. Engalycheva, E. A. Kozlovskaya   +4 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Selenium accumulation in leaves of perennial onions

Овощи России, 2009
It was determined that Selenium concentration in leaves of perennial onion was in the range of 161 to 201 mg/kg of dry matter. The highest concentration of Selenium was in leaves of Common Chives, and Siberian Chives.
N.A. Golubkina, A.F. Agafonov, N.S. Dudchenko   +2 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source