Results 111 to 120 of about 1,093,092 (310)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Improving seed potato quality in Ethiopia: a value chain perspective [PDF]

, 2016
In Ethiopia, use of low-quality seed potatoes by the majority of potato growers is associated with underdevelopment of the seed potato value chains. Three seed potato systems are present in Ethiopia: the informal seed system, the alternative seed system ...
Hirpa Tufa, A., Lommen, W.J., Meuwissen, M.P., Oude Lansink, Alfons G., Struik, Paul C., Tsegaye, A.   +5 more
core   +2 more sources

Barley seed survey shows quality problems

California Agriculture, 1963
Only 20% of the barley seed lots sampled in a two-year, 17-county survey—as reported in this study—met standards required of California certified barley seed.
M Miller, C Schaller, E Bruch, F Parsons
doaj  

Influence of Storage Containers and Seed Pelleting on Seed Quality in Brinjal (Solanum melongena L.) during Storage

Journal of Horticultural Sciences, 2008
The experiment was conducted using brinjal hybrid seeds cv. Arka Navneet. Seeds were pelleted with Bavistin, ZnSO4, MnSO4, DAP and Arappu leaf powder and stored in paper and polyethylene bags under ambient conditions for 12 months.
Satish Kumar, Basave Gowda, S Patil Shekhar   +2 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

A study of the relationship between seed quality and commercial sprouting quality of green gram (Vigna mungo L. Hepper) and black gram (Vigna radiata L. Wilczek) : a thesis presented in partial fulfilment of the requirement for the degree of Master of Applied Science in Seed Technology at Massey University, Palmerston North, New Zealand [PDF]

, 1998
Page 68 is missing from the original copy.Standard seed quality tests (seed moisture content, thousand seed weight, topographical tetrazolium, germination and seedling evaluation); vigour tests (accelerated ageing, conductivity, rate of germination and ...
DeFilippi, Joanne Maree
core  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Multivariate NIR studies of seed-water interaction in Scots Pine Seeds (Pinus sylvestris L.) [PDF]

, 2003
This thesis describes seed-water interaction using near infrared (NIR) spectroscopy, multivariate regression models and Scots pine seeds. The presented research covers classification of seed viability, prediction of seed moisture content, selection of ...
Lestander, Torbjörn
core  

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source