Results 91 to 100 of about 5,032,258 (310)
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Овощи России, 2015 28 May 2015, in Tashkent, Uzbekistan, the Ist International conference "Pink tomato. Production, consumption, market trends" was held. The problems of breedong, seed production of cultivars and hybrids of pink tomato, as well as increasing of consumer's ...
Sh. Alimov, M. M. Tareeva
doaj +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Gravimetric sorting to improve germination of Anogeissus leiocarpa seed lots
, 2015 Anogeissus leiocarpa is an important economical and cultural species which is used for dyeing cotton fabric and for reforestation and restoration plantings in West Africa, where it is protected.
Sacande, M. +5 more
core +1 more source
Seed treatments for improved germination of caper (Capparis spinosa) [PDF]
, 2004 [EN] This study analyses the effects of seven treatments for removing hardseededness and four for breaking physiological dormancy in caper seeds. Seeds were germinated in a growth chamber and the maximum germination percentage, the time to reach 50% of ...
Alagarda Pardo, José +5 more
core +1 more source
X-RAY DIFFRACTION METHOD FOR EVALUATION OF HETEROGENEOUS SEEDS OF GREEN VEGETABLE CROPS
Овощи России, 2015 Results of X-Ray diffraction analysis of inner structure of seeds of green vegetable crops are shown. The advantage of this method over conventional analysis is the informative value, safe-keeping and integrity of tested seeds.
F. B. Musaev +4 more
doaj +1 more source
Amide Modifications in the Seed Region of the Guide Strand Improve the On-Target Specificity of Short Interfering RNA. [PDF]
ACS Chem Biol, 2023 Richter M +6 more
europepmc +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source