Results 151 to 160 of about 5,032,258 (310)
Helix-7 in Argonaute2 shapes the microRNA seed region for rapid target recognition. [PDF]
EMBO J, 2018 Klum SM +4 more
europepmc +1 more source
IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
FEBS Open Bio, EarlyView.To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source
Efficient nearly orthogonal and space-filling Latin hypercubes [PDF]
, 2007 SEED Center ...
Cioppa, T.M., T.W. Lucas
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FEBS Open Bio, EarlyView.TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao +10 more
wiley +1 more source
PLASTID TRNL INTRON VARIABILITY IN FABOIDEAE SPECIES (FABACEAE)
Вавиловский журнал генетики и селекции, 2015 The intron located between the first and second nucleotide of the leucine tRNA anticodon is the only representative of group I introns in higher plants.
E. A. D’yachenko +3 more
doaj
In vitro generation of regulatory T cells: A challenging tool for studying immune aging in humans
FEBS Open Bio, EarlyView.In vitro induction of human regulatory T cells using standard protocols generates suppressive, Foxp3‐expressing CD4+ T cells independently of TGF‐β supplementation and donor age. Regulatory T (Treg) cells play a key role in immune tolerance and homeostasis.
Lynn Muller +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao +23 more
wiley +1 more source
Seeding patterns: the sources of regional diversification
, 2020 Relatedness has been largely acknowledged as a major driver of regional diversification: new industries grow out of technologically related industries by means of combinatorial knowledge dynamics and branching processes. However, by emphasizing the role of firms and entrepreneurs in new path creation, evolutionary scholars have not only underplayed the
openaire +1 more source
Hydrogel platforms for 3D cardiac tissue engineering and fibrotic disease modelling
FEBS Open Bio, EarlyView.Hydrogel‐based cardiac tissue models are advancing our understanding of heart health and disease. By incorporating electrical conductivity, aligned structures, and tunable mechanical properties, these platforms better replicate the complex environment of native heart tissue.
Harrison Porritt +2 more
wiley +1 more source
Seed provision and dryland crops in the semiarid regions of Eastern Kenya: [PDF]
"Over the last two decades, several seed-related programs have been initiated in eastern Kenya to improve farmers' access to quality seeds of dryland cereals and legumes. They are provided during two occasions, regular and emergency times. But very often,
Nagarajan, Latha +3 more
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