Results 51 to 60 of about 5,032,258 (310)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Nepal Vegetable Seed Study: Retailer Survey

, 2016
This study contains data that were collected to assess the status of vegetable seed retailers and markets across Nepal. The data contains information from 98 retailers from 20 districts in Nepal.
Seed Entrepreneurs' Association of Nepal (SEAN), International Food Policy Research Institute (IFPRI)   +1 more
core   +1 more source

RADISH CV. MOKHOVSKIY IS A SOURCE OF MS- AND MF-LINES AT BREEDING FOR HETEROSIS

Овощи России, 2015
Based on hybrid and inbreed population of radish cv. Mokhovskiy using CMS-ogura nine lines with 100% of male sterility and fertile maintainers were selected.
M. I. Fedorova, T. V. Zayachkovskaya, E. A. Domblides, A. S. Domblides   +3 more
doaj   +1 more source

Dormancy in native fruit seeds of the Brazilian South Region

COLLOQUIUM AGRARIAE, 2021
The aim of the present study was to investigate whether seeds from six native fruit species ofthe South Brazilian regionhad any type of dormancy, as well as, to verify if they havephotoblastism. The work was carried out at the Plant Physiology Laboratoryofthe Federal Technological University of Paraná –Câmpus Dois Vizinhos,
Kelli Pirola, Américo Wagner Junior, Marcelo Dotto, Darcieli Aparecida Cassol, Jean Carlo Possenti, Idemir Citadin   +5 more
openaire   +4 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

PROSPECTIVE OF DEVELOPMENT OF DOUBLED HAPLOID PLANTS OF CUCURBITACEAE FAMILY

Овощи России, 2015
In this review, the experience of Russian and foreign scientists in field of development of technology of doubled haploids (DHs) of Cucurbitaceae crops is summarized.
N. A. Shmykova, G. A. Khimich, I. B. Korotseva, E. A. Domblides   +3 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Analysis of Seed Potato Systems in Ethiopia [PDF]

, 2010
This study aimed to analyze the seed potato systems in Ethiopia, identify constraints and prioritize improvement options, combining desk research, rapid appraisal and formal surveys, expert elicitation, field observations and local knowledge. In Ethiopia,
Agajie Tesfaye, Hirpa, A., Oude Lansink, A.G.J.M., Willemien J. M. Lommen, Struik, P.C., Alfons Oude Lansink, Paul C. Struik, Miranda P. M. Meuwissen, Meuwissen, M.P.M., Tsegaye, A., Admasu Tsegaye, Lommen, W.J.M., Tesfaye, A., Adane Hirpa   +13 more
core   +1 more source

COMPOSITION OF ELEMENTS OF WINTER GARLIC (ALLIUM SATIVUM L.)

Овощи России, 2015
Ten varieties of winter garlic were tested for ability to accumulate macroand microelements. Genotype dependence was revealed. The most valuable varieties Strelets, Odintsovskiy Yubileyniy, Podnebesniy, Zaokskiy, and Replikant are characterized by high ...
T. M. Seredin, A. F. Agafonov, L. I. Gerasimova, L. V. Krivenkov   +3 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source