Results 111 to 120 of about 4,182,267 (328)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Taxonomic relationships in some Vicia species from Egypt, based on seed morphology and SDS-PAGE of seed proteins - doi: 10.4025/actascibiolsci.v35i4.19345

Acta Scientiarum: Biological Sciences, 2013
The seed morphology and seed proteins of 11 Vicia taxa from Egypt were studied. Macro- and micro-morphological characters, including seed shape, color, size, hilum shape and seed sculpture were described and analyzed.
Kadry Nabeh Abdel Khalik, Iman Hussien Al Gohary   +1 more
doaj   +1 more source

Seed germination traits shape community assembly along a hydroperiod gradient.

Annals of Botany, 2019
BACKGROUND AND AIMS Hydroperiod drives plant community composition in wetlands resulting in distinct zonation patterns. Here, we explored the role of seed germination traits in shaping wetland community assembly along a hydroperiod gradient. Specifically,
S. Rosbakh, S. Phartyal, P. Poschlod
semanticscholar   +1 more source

Invasive earthworms shape forest seed bank composition

Diversity and Distributions, 2015
AbstractAimTo assess how non‐native earthworm and non‐native plant invasions shape soil seed bank composition in deciduous temperate forests.LocationNew York State, USA.MethodsWe recorded earthworm density, earthworm biomass and vegetation composition in 12 deciduous forests and subsequently collected soil cores and recorded emergence of plant species ...
Victoria Nuzzo, Andrea Dávalos, Bernd Blossey   +2 more
openaire   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Seed Metrics for Genetic and Shape Determinations in African Yam Bean [Fabaceae] (Sphenostylis stenocarpa Hochst. Ex. A. Rich.) Harms [PDF]

, 2010
The metric measures on seeds, their correlation and relationship are important for systematic breeding for seed yield and shape determination. Variations among eighty genotypes of African yam bean (AYB) for six metric seed characters (seed length ...
Adewale, B. D., Aremu, C. O., Dumet, D. J., Kehinde, O. B., Popoola, J.O   +4 more
core   +2 more sources

Comparison of shape quantification methods for genomic prediction, and genome-wide association study of sorghum seed morphology

PLoS ONE, 2019
Seed shape is an important agronomic trait with continuous variation among genotypes. Therefore, the quantitative evaluation of this variation is highly important.
Lisa Sakamoto, H. Kajiya-Kanegae, Koji Noshita, H. Takanashi, Masaaki Kobayashi, Toru Kudo, K. Yano, Tsuyoshi Tokunaga, N. Tsutsumi, H. Iwata   +9 more
semanticscholar   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Milling Performance and Other Quality Traits Affected by Seed Shape in Isogenic Lines of Desi Chickpea (Cicer arietinum L.)

, 2012
Milling of pulses generally involves removal of the seed coat and splitting of the cotyledons to produce splits or ‘dhal’. The aim of this research was to investigate whether seed shape affected seed quality using two sets of near-isogenic lines ...
J. Wood, E. J. Knights, S. Harden, M. Choct   +3 more
semanticscholar   +1 more source