Results 131 to 140 of about 2,387,160 (293)
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Seed mass and shape are related to persistence in a sandy soil in northern China
, 2011 Whether and how seed mass and shape are related to seed persistence in soil is a controversial topic in plant ecology. There is little information on this relationship in sandy habitats. We tested whether or not this pattern is retained among 141 species
Zhao Ling-Ping +3 more
core
How Variables Like Parent, Seed Size and Desiccation Time Affect Seed Deterioration of Quercus macrocarpa L. [PDF]
, 2009 Desiccation sensitivity is the main characteristic of recalcitrant seeds that poses limitations to practices such as storage and direct seeding. This study investigated the effect of parent tree, seed size, and desiccation time on seed variables ...
Iakovoglou, Valasia +4 more
core
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Relationship between seed size, shape, and persistence in the Hungarian flora
The destiny of seeds inside the soil seed bank is determined by the complex interaction between seed morphology and seed persistency. The morphological properties of seeds, including their size and shape, are crucial in determining the dynamics of seed ...
Khashkhuu, Oyundari
core
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Legume seed production and research in Europe [PDF]
, 2002 Legume seed production and research in ...
Boelt, B.
core +1 more source
Exposing the error hidden in plain sight: A critique of Calder's (1983) group selectionist seed-dispersal hypothesis for mistletoe "mimicry" of host plants. [PDF]
Ecol Evol, 2023 Harms KE +3 more
europepmc +1 more source