Results 111 to 120 of about 2,387,160 (293)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Ecology and EvolutionDue to the expansion of road networks and the use of de‐icing salt, numerous salt‐tolerant plant species spread along roadsides worldwide. One of the most striking examples is a coastal halophyte, Plantago coronopus, which has been dispersing along road ...
Henrietta Bak +7 more
doaj +1 more source
Acta Scientiarum: Biological Sciences, 2013 The seed morphology and seed proteins of 11 Vicia taxa from Egypt were studied. Macro- and micro-morphological characters, including seed shape, color, size, hilum shape and seed sculpture were described and analyzed.
Kadry Nabeh Abdel Khalik +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Computational Methods for Shape Manipulation in generation : a literature review [PDF]
, 2010 In this paper we will present a state of the art of the descriptive and generative models for shape. We will present several different approaches for the manipulation of shape in computational systems: numerical models, graph models, descriptive models ...
AOUSSAT, Améziane +3 more
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Nepal Vegetable Seed Study: Household Survey
, 2017 This study contains data that were collected to assess the status of vegetable seed production across Nepal. The data contains information from 600 households from 20 districts in Nepal.
Seed Entrepreneurs' Association of Nepal (SEAN) +1 more
core +1 more source
Seed micromorphological characteristics in Ochradenus and Reseda and their taxonomic significance in Iran [PDF]
رستنیهاSeed micromorphology of 16 taxa from Ochradenus and Reseda (Resedaceae) was examined using stereomicroscope and scanning electron microscope. In the present study, three quantitative (length, width, and ratio of seed length/seed width) and 10 qualitative
Mahtab Asgari Nematian, Mehdi Heidarian
doaj +1 more source