Results 131 to 140 of about 4,182,267 (328)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Seed Morphological Analysis in Species of Vitis and Relatives
HorticulturaeSeed shape descriptions of species of Vitis have traditionally been based on adjectives comparing overall shape with geometric figures, such as oval, elongated oval, and pear-shaped, corresponding to higher values of the Stummer index (lower aspect ratio)
José Javier Martín-Gómez +6 more
doaj +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
X-ray spectra of hot accretion flows
, 2014 We study radiative properties of hot accretion flows in a general relativistic model with an exact treatment of global Comptonization, developed in our recent works.
Niedzwiecki, Andrzej +2 more
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Genome-wide association mapping of seed shape-related traits in cotton using SSR markers
Journal of Cotton ResearchBackground Cotton is a significant crop for fiber production; however, seed shape-related traits have been less investigated in comparison to fiber quality.
Irfan Ali Siddho +10 more
doaj +1 more source
A Distributed Epigenetic Shape Formation and Regeneration Algorithm for a Swarm of Robots
, 2018 Living cells exhibit both growth and regeneration of body tissues. Epigenetic Tracking (ET), models this growth and regenerative qualities of living cells and has been used to generate complex 2D and 3D shapes.
Cheng Jimming +3 more
core +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
, 2018 We compare the $\gamma$-ray spectra from 10 middle-aged supernova remnants (SNRs), which are interacting with molecular clouds (MCs), with the model prediction from widely used escaping scenario and direct interaction scenario.
Tang, Xiaping
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source