Results 51 to 60 of about 158,285 (306)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Kafirin structure and functionality [PDF]

, 2006
The structural and functional properties of kafirins are reviewed. Three classes of kafirin: the a, ß and ? forms have been identified at the protein level and one, the d, has been identified only at the gene and transcript levels.
Argos, Bean, Bravo, Buffo, Bugs, Byers, Cabra, Chamba, Coleman, Correia, Da Silva, Dahlin, Dalcol, Das, De Barros, DeRose, Duodo, Duodo, Duodo, El Nour, Emmambux, Evans, Forato, Forato, Gao, Garratt, Gou, Grant, Hamaker, Hsu, I. Delgadillo, Kogan, Kogan, Kreis, Leite, Leite, Matsushima, Mazhar, N.G. Halford, Nunes, Nunes, Oria, Osborne, P.R. Shewry, P.S. Belton, Parker, Paulis, Pons, Prat, Shewry, Shewry, Shewry, Shewry, Shull, Shull, Tatham, Watterson, Wilson, Wilson, Woo, Wu   +60 more
core   +1 more source

Seed storage protein variation in Arachis species [PDF]

Genome, 1994
Seventy-two accessions, representing 22 species from sections Arachis, Erectoides, Extranervosae, and Triseminalae of the genus Arachis, were screened for seed storage protein polymorphism. Variation was detected between sections, between genome types, between species, and in some cases between different accessions of the same species or different ...
Lanham, P G, Forster, B P, McNicol, P, Moss, J P, Powell , W   +4 more
openaire   +3 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Biochemical investigations on vigour enhancement in aged seeds upon seed priming in onion [PDF]

, 2016
Loss in seed quality that occurs during all process, from maturation in the field to storage, leads to seed deterioration. Storage of onion seeds under ambient, hot and humid conditions is very problematic since these conditions deteriorate seed quality ...
Amruta, N., Bhanuprakash, K., Manjunatha, B., Sarika, G., Umesha, Umesha, Vasudevan, S.N.   +5 more
core   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Soybeans grown in the Chernobyl area produce fertile seeds that have increased heavy metal resistance and modified carbon metabolism. [PDF]

PLoS ONE, 2012
Plants grow and reproduce in the radioactive Chernobyl area, however there has been no comprehensive characterization of these activities. Herein we report that life in this radioactive environment has led to alteration of the developing soybean seed ...
Katarína Klubicová, Maksym Danchenko, Ludovit Skultety, Valentyna V Berezhna, Lubica Uvackova, Namik M Rashydov, Martin Hajduch   +6 more
doaj   +1 more source

Transcription Factor DOF4.1 Regulates Seed Longevity in Arabidopsis via Seed Permeability and Modulation of Seed Storage Protein Accumulation

Frontiers in Plant Science, 2022
Seed longevity is modulated by multiple genetic factors in Arabidopsis thaliana. A previous genome-wide association study using the Elevated Partial Pressure of Oxygen (EPPO) aging assay pinpointed a genetic locus associated with this trait.
Regina Niñoles, Carmen Maria Ruiz-Pastor, Paloma Arjona-Mudarra, Jose Casañ, Joan Renard, Eduardo Bueso, Ruben Mateos, Ramón Serrano, Jose Gadea   +8 more
doaj   +1 more source

Enhancing microRNA167A expression in seed decreases the α-linolenic acid content and increases seed size in Camelina sativa. [PDF]

, 2019
Despite well established roles of microRNAs in plant development, few aspects have been addressed to understand their effects in seeds especially on lipid metabolism.
Grabowski, Paul, Lu, Chaofu, Mu, Xiaopeng, Na, GunNam, Schmutz, Jeremy   +4 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source