Results 81 to 90 of about 158,285 (306)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Effect of salicylic acid induction on germination, radicle length, and protein content in chickpea seedlings [PDF]

open access: yesJournal of Seed Science
: Germination is a process of high metabolic activity in plants that involves the use of storage components present in seeds for seedling development.
Diana Elizabeth Escobedo-Álvarez   +5 more
doaj   +1 more source

Developments in plant breeding for improved nutritional quality of soya beans II. Anti-nutritional factors [PDF]

open access: yes, 2000
Nutritional value of most plant materials is limited by the presence of numerous naturally occurring compounds which interfere with nutrient digestion and absorption.
Clarke, E, Wiseman, J
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Unraveling the Molecular Basis of Seed Viability and Longevity through Integrated Proteomic and Metabolomic Approaches

open access: yesInternational Journal of Bio-Resource and Stress Management
This review considered the key factors that regulated seed viability, including environmental conditions and genetic effects and the molecular processes involved during seed storage and germination.
Sultan Singh   +6 more
doaj   +1 more source

Wine Fining with Plant Proteins [PDF]

open access: yes, 2019
: Fining treatments involve the addition of a substance or a mixture to wine, and are generally carried out in order to clarify, stabilize or modify the wine\u2019s organoleptic characteristics. Usually these fining agents will bind the target compound(s)
Curioni, Andrea   +2 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Immature Seed Endosperm and Embryo Proteomics of the Lotus (Nelumbo Nucifera Gaertn.) by One-Dimensional Gel-Based Tandem Mass Spectrometry and a Comparison with the Mature Endosperm Proteome

open access: yesProteomes, 2015
Lotus (Nelumbo nucifera Gaertn.) seed proteome has been the focus of our studies, and we have recently established the first proteome dataset for its mature seed endosperm. The current study unravels the immature endosperm, as well as the embryo proteome,
Carlo F. Moro   +7 more
doaj   +1 more source

Assessment of genetic diversity of different Hyrcanian Boxwood populations for ex situ conservation in Natural Resources Gene Bank of Iran [PDF]

open access: yesعلوم و فناوری بذر ایران, 2019
Evaluation of necessary and sufficient population number of a species in seed collection program requires knowledge of genetic diversity and differentiation.
پروین صالحی شانجانی   +3 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

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