Results 71 to 80 of about 39,401 (308)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Assessment of hemp seed vigour [PDF]

open access: yes, 2019
The seed vigour can be explained and described as the theoretical capacity of the seed which allows it to accomplish its substantial function under different environmental conditions. The key purpose of testing seed vigour as an underlying physiological seed characteristic is to establish more susceptible and precise seed quality parameters than a ...
Jovičić, Dušica   +6 more
openaire  

Characterization of Sorghum germplasm for various qualitative traits [PDF]

open access: yes, 2017
Present study was performed to characterize 750 germplasm lines with 4 checks namely CSV17, CSV20, CSV27 and CSV21F for various qualitative traits of Sorghum.
Bharti, Baudh   +6 more
core   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Dependence of the legume seeds vigour on their maturity and method of harvest

open access: yesActa Societatis Botanicorum Poloniae, 2014
Several methods were used to study 'the vigour and viability of legume seeds (Pisum sativum L. cv. Hamil, Piston arvense L. cv. Mazurska and Lupinus luteus L. cv. Tomik) harvested at three main stages of seed repening (green, wax and full).
Stanisław Grzesiuk, Ryszard Górecki
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Biochemical investigations on vigour enhancement in aged seeds upon seed priming in onion [PDF]

open access: yes, 2016
Loss in seed quality that occurs during all process, from maturation in the field to storage, leads to seed deterioration. Storage of onion seeds under ambient, hot and humid conditions is very problematic since these conditions deteriorate seed quality ...
Amruta, N.   +5 more
core   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

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