Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Effects of Macronutrients on Seed Quality and Profitability Analysis of Sunflower Production in Northwest Pakistan [PDF]
Potassium (K) and phosphorus (P) application to sunflower (Helianthus annus L.) reduced cost of production, increased seed oil and protein concentration, yield and net returns on the K and P deficient soils in Northwest Pakistan.
Almas, Lal K. +3 more
core +1 more source
Comparing Hemp Seed Yields (Cannabis sativa L.) of an On-Farm Scientific Field Experiment to an On-Farm Agronomic Evaluation Under Organic Growing Conditions in Lower Austria [PDF]
, 2004 Hemp seed yields of the variety Fedora-19 in an on-farm scientific field experiment on small plots and in an on-farm evaluation in 11 hemp fields under practical organic growing conditions in Lower Austria were compared to give a realistic view of the ...
Lissek-Wolf, G. +2 more
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Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Selection indices for yield in rabi sorghum (Sorghum bicolor L. Moench) genotypes [PDF]
Electronic Journal of Plant Breeding, 2012 Various selection indices were constructed for yield in rabi sorghum genotypes using 45 genotypes. Among various traits,plant height, 1000-seed weight and fodder yield had significant and positive genotypic correlation with the seed yield perplant. Among
C.V.Sameer Kumar, Ch.Sreelakshmi and D.Shivani
doaj
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Impact of Some of the Important Insecticides on Final Seed Yield of Bell Pepper (Capsicum annuum L.)
International Journal of Bio-Resource and Stress Management, 2018 The present studies were carried out at Department of Seed Science and Technology, Dr. Y. S. Parmar University of Horticulture and Forestry, Nauni, Solan, Himachal Pradesh, India during kharif season 2013 to see the impact of some of the important
Har Lal Meena +4 more
doaj
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Potential des Anbaus von Saflor (Carthamus tinctorius L.) unter den Bedingungen des Ökologischen Landbaus in Mitteleuropa [PDF]
, 2005 Under organic farming conditions, twenty safflower genotypes were tested for genotype-by-environment interaction (GxE) and stability across four locations in Germany and Switzerland for seed yield and oil content..
Claupein, Wilhelm +3 more
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