Results 41 to 50 of about 589,179 (294)
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
New Phytologist, 1987 SummaryThe involvement of four factors (life history, predation, possession of a persistent seed bank and seedling establishment) in the evolution of seed size in flowering plants is discussed. Among herbacaeous plants, biennials seem to have larger seeds than annuals and perennials, a difference which may explain the capacity of some biennials to ...
openaire +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Recent Advancements and Perspectives in UAS-Based Image Velocimetry
Drones, 2021 Videos acquired from Unmanned Aerial Systems (UAS) allow for monitoring river systems at high spatial and temporal resolutions providing unprecedented datasets for hydrological and hydraulic applications.
Silvano Fortunato Dal Sasso +2 more
doaj +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Automated Seeding in Hydroponic Greenhouse With a Dual-Arm Robotic System
IEEE AccessAutomation in agriculture, often referred to as Agriculture 4.0, has attracted significant interest in recent decades. The integration of technologies like artificial intelligence, robotic manipulation, and autonomous navigation, commonly used in ...
Daniel Rodriguez-Nieto +2 more
doaj +1 more source
Inhibition of synucleinopathic seeding by rationally designed inhibitors
eLife, 2020 Seeding, in the context of amyloid disease, is the sequential transfer of pathogenic protein aggregates from cell-to-cell within affected tissues. The structure of pathogenic seeds provides the molecular basis and enables rapid conversion of soluble ...
Smriti Sangwan +9 more
doaj +1 more source
Metals, 2022 By combined numerical simulations and unidirectional solidification experiments, the temperature field evolution of seeding for nickel-based single-crystal superalloys was studied.
Songsong Hu +6 more
doaj +1 more source
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
Testing site selection for seeding trials using hatchery reared juvenile Haliotis mariae Wood, 1828 along the western Dhofar coast, Arabian Sea, Sultanate of Oman [PDF]
Songklanakarin Journal of Science and Technology (SJST), 2015 In order to test site selection and seeding methodology hatchery reared juvenile Haliotis mariae with an average shell-length 30-52 mm were seeded along the Dhofar coast during the winter months of the NE monsoon.
Schalk de Waal +4 more
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