Results 81 to 90 of about 589,179 (294)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Determination of seeding cycle by stem analysis of three beech stands [PDF]

تحقیقات جنگل و صنوبر ایران, 2005
Three natural stands of beech (Fagus orientalis Lipsky) at different parts of Caspian Forests of Iran (Kelardasht, Sangdeh and Gorgan) were chosen to determine their seeding cycle by stem analysis.
Ali Reza Mirbadin, Manoochehr Namiranian
doaj  

Seed Number, Seed Size and Seed Diversity in Washington Lupin (Lupinus polyphyllus Lindl.) [PDF]

, 2001
Tadeusz Aniszewski
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Generation of a Potato Radiation Mutation System to Analyse the Features of Radiation Mutant RM1

Agronomy
Potatoes are widely planted worldwide and are the third most important food crop. Mutation breeding involves the artificial use of various physical and chemical factors to induce plants to produce new genotypes.
Liqin Li, Linjuan Jiang, Bi Ren, Yifei Lu, Chengcheng Lv, Chenrui Wang, Liming Lu, Shimin Yang   +7 more
doaj   +1 more source

ABC Transporter-Mediated Transport of Glutathione Conjugates Enhances Seed Yield and Quality in Chickpea [PDF]

, 2019
Udita Basu, Hari D. Upadhyaya, Rishi Srivastava, Anurag Daware, Naveen Malik, Akash Sharma, Deepak Bajaj, Laxmi Narnoliya, Virevol Thakro, Alice Kujur, Shailesh Tripathi, C. Bharadwaj, Venkatraman Hegde, Ajay Kumar Pandey, A. K. Singh, Akhilesh K. Tyagi, Swarup K. Parida   +16 more
openalex   +1 more source

Seed Dormancy Release and Germination Requirements of Cinnamomum migao, an Endangered and Rare Woody Plant in Southwest China

, 2022
Jing‐Zhong Chen, Xiaolong Huang, Xiao Xuefeng, Jiming Liu, Xiaofeng Liao, Qing-wen Sun, Liang Peng, Lan Zhang   +7 more
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Research on an effective artificial regeneration method for selected commercially important coniferous tree species on a large sanitation cut site situated in the Javorníky Mts., Western Carpathians

Journal of Forest Science
In response to the decline of Central European spruce monocultures driven by various factors, the Demonstration Object of Reconstruction of Spruce Forests (DORS) was established in Husárik locality, Javorníky Mts., northwestern Slovakia.
Martin Belko, Anna Tučeková, Roman Longauer, Valéria Longauerová, Vladimír Mačejovský, Ivan Horvát   +5 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source