Results 61 to 70 of about 327,495 (306)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Continuous repetition rate tuning with timing window independent self-seeding of a gain-switched Fabry-PÉrot Laser [PDF]

, 2007
In this work, we propose a novel self-seeding technique that yields timing window independent operation allowing continuous repetition rate tuning of the self-seeded gain-switched (SSGS) laser.
Anandarajah, Prince M., Barry, Liam P., Maher, Robert D.   +2 more
core   +1 more source

Improving Groundcover Establishment Through Seed Rate, Seed Ratio, and Hydrophilic Seed Coating

Agronomy
Kentucky bluegrass (KBG) is well-suited as a perennial groundcover in corn production due to its vigorous growth during the fall and spring and its natural dormancy during the summer, aligning with the corn growing season. However, seeds of KBG germinate slowly, potentially resulting in poor stand establishment in the Midwest, USA.
Jack Moran, A. Susana Goggi, Ken J. Moore, Shui-zhang Fei, Shelby Gruss   +4 more
openaire   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Tillage Radish Planting Date x Seeding Rate Trial [PDF]

, 2016
Farmers are interested in growing tillage radishes as they may potentially offer many environmental and economic benefits. Tillage radishes are quick at scavenging excess nitrogen (N), provide good ground cover, and break down very quickly in the spring ...
Brigham, Nate, Cummings, Erica, Darby, Heather, Emick, Hillary, Gupta, Abha, Ziegler, Sara   +5 more
core   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Cover Crop Planting Date x Seeding Rate Trial [PDF]

, 2012
When corn silage is harvested in the fall, the entire plant is removed, leaving the soil exposed through the winter. Many farmers have started to plant cover crops following corn harvest because of the multitude of benefits cover cropping brings to soil ...
Burke, Conner, Cummings, Erica, Darby, Heather, Harwood, Hannah, Madden, Rosalie, Monahan, Susan   +5 more
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Corn Row Spacing and Seeding Rate

, 2017
Corn plant populations have increased at approximately 400 plants/acre per year over the last two decades. Seeding rates are now commonly 32,000 to 38,000 seeds/acre. Additionally, grain yields are increasing at approximately 1.8 bushels/acre per year since 1996.
Licht, Mark, Huffman, Chad
openaire   +5 more sources

Sunflower Seeding Rate x Nitrogen Rate Trial Report [PDF]

, 2010
The 2010 growing season was warmer and slightly wetter than normal through the majority of the spring. The month of May was considerably drier than normal, though June’s rainfall exceeded 30-year averages.
Cummings, Erica, Darby, Heather, Gervais, Amanda, Halteman, Philip, Madden, Rosalie   +4 more
core   +1 more source