Results 91 to 100 of about 754,891 (308)

Gene duplication and clustering underlie the conservation and diversification of benzylisoquinoline alkaloid biosynthesis in plants

Nature Communications
Benzylisoquinoline alkaloids (BIAs), comprising ~2500 compounds with pharmacological significance, are well-studied in Ranunculales but poorly understood in Magnoliids, an early-diverging angiosperm group.
Changheng Shan, Xuan Zhou, Jiaojiao Zhu, Aatif Rashid, Jianhua Wang, Ning An, Changjian Zhang, Wenjuan Ji, Baosong Cai, Ke Wu, Sheng Wang, Zhenhua Liu   +11 more
doaj   +1 more source

Morphometric Analysis of Grape Seeds: Looking for the Origin of Spanish Cultivars

Seeds
The Vitis IMIDRA collection contains 3699 entries, representing a significant percentage of the variation in traditional and commercial Vitis cultivars used in Spain.
Francisco Emanuel Espinosa-Roldán, José Luis Rodríguez-Lorenzo, José Javier Martín-Gómez, Ángel Tocino, Víctor Ruiz Martínez, Adrián Remón Elola, Félix Cabello Sáenz de Santamaría, Fernando Martínez de Toda, Emilio Cervantes, Gregorio Muñoz-Organero   +9 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

To Clamp or Not to Clamp: Enhancing Seed Endophyte Metabarcoding Success

Seeds
Seed microbes play crucial roles in plant health, but studying their diversity is challenging due to host DNA contamination. This study aimed to optimise methodologies for investigating seed microbiomes across diverse plant species, focusing on the ...
Allison A. Mertin, Linda L. Blackall, Douglas R. Brumley, Edward C. Y. Liew, Marlien M. van der Merwe   +4 more
doaj   +1 more source

Characterization and downstream mannose phosphorylation of human recombinant α-L-iduronidase produced in Arabidopsis complex glycan-deficient (cgl) seeds [PDF]

, 2013
This work was supported by a Wellcome Trust award to TMG.Mucopolysaccharidosis (MPS) I is a lysosomal storage disease caused by a deficiency of α-L-iduronidase (IDUA) (EC 3.2.1.76); enzyme replacement therapy is the conventional treatment for this ...
Brooks, Doug, Gloster, Tracey M., Vocadlo, D.J., Brooks, D., Kolarich, Daniel, Kermode, Allison R, Kermode, Allison R., Haselhorst, T., Qian, Y., Gloster, Tracey M, Qian, Yi, Gloster, Tracey, Kolarich, D., Haselhorst, Thomas, Packer, N.H., Pierce, Owen, He, X., von Itzstein, Mark, Gloster, T.M., Packer, Nicolle H., He, Xu, Pierce, O., Packer, Nicolle H, Vocadlo, David J, von Itzstein, M., Kermode, A.R., Vocadlo, David J.   +26 more
core   +1 more source

Proteomic Analysis of the Effect of Accelerated Ageing on Allium mongolicum Seeds

, 2023
Seed propagation is the most commonly used method for producing Allium mongolicum seeds. However, as storage time increases, the seeds may suffer from ageing to varying degrees. This study aims to investigate the proteome expression of A.
Dong Zhang, Fenglan Zhang, Jiecai Liu, Xiaoqing Song, Chuanzong Yu, Zhongren Yang, Xiaoyan Zhang   +6 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

In Vitro Germination of the Mediterranean Xerophytes Thymelaea hirsuta and Thymelaea tartonraira ssp. tartonraira as Affected by Scarification, Temperature, Photoperiod and Storage

Seeds
With the aim of developing an efficient propagation method for the exploitation of Thymelaea hirsuta and T. artonraira ssp. tartonraira in the xeriscaping and pharmaceutical industry, the effects of the following were examined on the in vitro germination
Aikaterini N. Martini, Maria Papafotiou
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

UVB Stress Induced Changes in Germination and Carbohydrate Mobilization in Chenopodium Quinoa Willd. Seeds

Seeds
Chenopodium quinoa Willd. (quinoa) is a very promising crop due to its nutraceutical properties and strong tolerance to extreme conditions, including high UVB. However, the physiological mechanisms underlying its adaptation to high UVB are still unclear,
Marco Carli, Lorenzo Guglielminetti, Thais Huarancca Reyes   +2 more
doaj   +1 more source