Results 111 to 120 of about 754,891 (308)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Exploring the Morpho-Physiological Dormancy and Germination Potential of Paeonia peregrina Mill. Seeds In Vitro

Seeds
Herbaceous peonies, specifically the Balkan–Anatolian Paeonia peregrina Miller, are species with various uses such as ornamental and garden purposes, or they can be cut as flowers or potted, or they can be eaten or used for medicinal purposes due to the ...
Virginia Sarropoulou, Eleni Maloupa, Katerina Grigoriadou   +2 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

QTL Identification of Hull Color for Foxtail Millet [Setaria italica (L.) P. Beauv.] Through Four Phenotype Identification Strategies in a RIL Population

Seeds
The foxtail millet exhibits a diverse range of hull colors, which are crucial indicators for assessing its nutritional and economic value. However, the molecular regulatory mechanisms that govern the hull color of foxtail millet are largely unknown at ...
Zhixiu Ma, Shaohua Chai, Yongjiang Wu, Yujie Li, Huibing Han, Hui Song, Jinfeng Gao, Baili Feng, Pu Yang   +8 more
doaj   +1 more source

Fedco Seeds and Supplies 2019 [PDF]

, 2019
When is a seed catalog more than a seed catalog? When it is the Fedco Seed catalog. Fedco, founded in 1978, is a worker-consumer cooperative in Maine known for promoting the ideals of cooperation, transparency, and the common ownership of seeds.
Fedco Seeds
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Kale Seed Germination and Plant Growth Responses to Two Different Processed Biostimulants from Pyrolysis and Hydrothermal Carbonization

Seeds
The cost of producing organic crops is increasing. Agricultural wastes can be used as biostimulants to increase plant growth and productivity and reduce the dependence on chemical fertilizers.
Yuxuan Tang, Raphael Ofoe, Lokanadha R. Gunupuru, Dengge Qin, Lord Abbey   +4 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Probing the Impact of Seed Coat Removal on the Germination Performance of Bitter Gourd (Momordica charantia) Using an Image Analyzer

Seeds
The germination speed and completeness of bitter gourd seeds were enhanced using two seed coat treatments: scarification and removal of the seed coat. In comparison to the scarified seed and control, removing the seed coat improved the germination speed ...
Roopashree Byregowda, Nethra Nagarajappa, Kadurappa Madhusudan, Thimmappa Krishnappa Nagarathna, Sharankumar Ashok Kesaratagi   +4 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source