Results 121 to 130 of about 644,839 (318)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Seed Germination of Garberia heterophylla (W. Bartram) Merr. & F. Harper, a Pollinator Plant with Ornamental Appeal

Seeds
Seed propagation is the primary means of reproducing many native and endemic species, including garberia [Garberia heterophylla (W. Bartram) Merrill & F. Harper].
Grace Carapezza, Sandra B. Wilson, Mica McMillan, Edzard van Santen   +3 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

[Affiches de Just Seeds (Collectif)]

Diverses affiches créées par Just Seeds (Collectif)

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Fedco Seeds 1989

, 1989
When is a seed catalog more than a seed catalog? When it is the Fedco Seed catalog. Fedco, founded in 1978, is a worker-consumer cooperative in Maine known for promoting the ideals of cooperation, transparency, and the common ownership of seeds.
Fedco Seeds
core  

Innovative Approaches for Engineering the Seed Microbiome to Enhance Crop Performance

Seeds
Seed science is the comprehensive study of seeds. It encompasses their biology, production, technology, genetics, physiology, ecology, and applications in agriculture and conservation.
Piao Yang, Ling Lu, Abraham Condrich, Gavin A. Muni, Sean Scranton, Shixiang Xu, Ye Xia, Shuai Huang   +7 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Fedco Seeds 2018

, 2018
When is a seed catalog more than a seed catalog? When it is the Fedco Seed catalog. Fedco, founded in 1978, is a worker-consumer cooperative in Maine known for promoting the ideals of cooperation, transparency, and the common ownership of seeds.
Fedco Seeds
core  

Potential Use of Herbicide Seed Safener and Pre-Emergent Residual Herbicides When Establishing Tropical Perennial Grasses—A Preliminary Study

Seeds
Annual grass weeds can provide significant competition to an establishing sown tropical perennial grass pasture. At least two years of grass weed control prior to sowing is required to reduce the weed seed bank.
Suzanne P. Boschma, Hugh W. McDouall, Jonathan W. McLachlan   +2 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source