Results 71 to 80 of about 374,965 (268)

Rhizobium Inoculants Mitigate Corn Herbicide Residual Effects on Soybean Germination

Seeds
Corn residual herbicides offer a practical approach to comprehensive weed management throughout the growing season. However, the use of residual pre-emergence herbicides can have a negative impact on crops grown in succession or within a rotation.
Ncomiwe Maphalala, Alaina Richardson, Sabrina Quevedo Sastre, Aricia Ritter Correa, Fernanda Reolon de Souza, Te Ming Tseng   +5 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Assessment of Optimal Seeding Rate for Fine and Coarse Rice Varieties Using the Direct Seeded Rice (DSR) Method

Seeds
Rice (Oryza sativa L.) is one of the most crucial cereal crops worldwide, serving as a staple food for a significant portion of the global population.
Atif Naeem, Madad Ali, Ahmad Jawad, Asif Ameen, Mehwish, Talha Liaqat, Samreen Nazeer, Muhammad Zubair Akram, Shahbaz Hussain   +8 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Biostimulant Effect and Antioxidant Responses of Carrot Extract and the Viability of Rice Seeds Under Salt Stress

Seeds
Bioactive compounds in plants, such as carrots, have been widely used for their benefits. In agriculture, their potential as biostimulants still needs to be investigated, especially for their possible antioxidant action in plants subjected to abiotic ...
Sheila Bigolin Teixeira, Stefânia Nunes Pires, Caroline Hernke Thiel, Cristiane Deuner, Diogo da Silva Moura, Natalia da Silva Garcia, Filipe Selau Carlos, Fernanda Reolon de Souza, Te Ming Tseng, Sidnei Deuner   +9 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Effectiveness of Pre-Sowing Treatments on Seed Germination of Nine Acacia Species from Al-Baha Region in Saudi Arabia

Seeds
Acacia species are important trees in arid ecosystems due to their diverse ecological roles, such as providing vegetation cover, community structures, food resources for animals, soil stabilization, and erosion prevention.
Ali A. Alzandi, Ibrahim M. Aref, Nels Grevstad   +2 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Chemopreventive Potential of Oils Extracted from Seeds of Three Annona Species

Seeds
Annona fruit, leaves, seeds, roots, and bark have been conventionally used in many countries for medical treatments as they are considered ideal sources of pharmacologically active compounds, but Annona remains an underutilized fruit in many countries ...
Prabash Attanayake, Dinesha Rupasinghe, Ashoka Gamage, Terrence Madhujith, Othmane Merah   +4 more
doaj   +1 more source