Results 61 to 70 of about 374,965 (268)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Exploring the Morpho-Physiological Dormancy and Germination Potential of Paeonia peregrina Mill. Seeds In Vitro

Seeds
Herbaceous peonies, specifically the Balkan–Anatolian Paeonia peregrina Miller, are species with various uses such as ornamental and garden purposes, or they can be cut as flowers or potted, or they can be eaten or used for medicinal purposes due to the ...
Virginia Sarropoulou, Eleni Maloupa, Katerina Grigoriadou   +2 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

QTL Identification of Hull Color for Foxtail Millet [Setaria italica (L.) P. Beauv.] Through Four Phenotype Identification Strategies in a RIL Population

Seeds
The foxtail millet exhibits a diverse range of hull colors, which are crucial indicators for assessing its nutritional and economic value. However, the molecular regulatory mechanisms that govern the hull color of foxtail millet are largely unknown at ...
Zhixiu Ma, Shaohua Chai, Yongjiang Wu, Yujie Li, Huibing Han, Hui Song, Jinfeng Gao, Baili Feng, Pu Yang   +8 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Action of defense activator and foliar fungicide on the control of Asiatic rust and on yield and quality of soybean seeds

Journal of Seed Science
The objective of this study was to evaluate the influence of fungicide application (PrioriXtra®, azoxystrobin + ciproconazole) and defense activator (Bion®, acibenzolar-S-methyl) on the control of Asiatic rust (Phakopsora pachyrhizi), as well as the ...
Bruno Oliveira Carvalho, João Almir Oliveira, Everson Reis Carvalho, Vinícius de Andrade, Thaís Francielle Ferreira, Leandro Vilela Reis   +5 more
doaj  

Kale Seed Germination and Plant Growth Responses to Two Different Processed Biostimulants from Pyrolysis and Hydrothermal Carbonization

Seeds
The cost of producing organic crops is increasing. Agricultural wastes can be used as biostimulants to increase plant growth and productivity and reduce the dependence on chemical fertilizers.
Yuxuan Tang, Raphael Ofoe, Lokanadha R. Gunupuru, Dengge Qin, Lord Abbey   +4 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Probing the Impact of Seed Coat Removal on the Germination Performance of Bitter Gourd (Momordica charantia) Using an Image Analyzer

Seeds
The germination speed and completeness of bitter gourd seeds were enhanced using two seed coat treatments: scarification and removal of the seed coat. In comparison to the scarified seed and control, removing the seed coat improved the germination speed ...
Roopashree Byregowda, Nethra Nagarajappa, Kadurappa Madhusudan, Thimmappa Krishnappa Nagarathna, Sharankumar Ashok Kesaratagi   +4 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source