Results 51 to 60 of about 644,839 (318)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Quality of Immature and Mature Pepper (Capsicum annuum L.) Seeds in Relation to Bio-Priming with Endophytic Pseudomonas and Bacillus spp.

, 2021
Fruit maturity for seed production can occur at various times because of the continual flowering of pepper plants. Accordingly, seeds with different maturity are acquired as the fruits are collected in a single harvest.
Didem Canik Orel, Hilal Okyay, Kutay Coskun Yildirim, Ibrahim Demir, Mukerrem Melis Gursan   +4 more
core   +1 more source

Effects of Marquandomyces marquandii SGSF043 on Maize Growth Promotion and Soil Enzyme Activity

Seeds
In order to further clarify the growth-promoting effect of the non-core Metarhizium sp. Marquandomyces marquandii on plants, M. marquandii SGSF043, which was obtained via pre-screening in the laboratory, was selected as a test strain and the seed soaking
Xu Zheng, Bo Zhang, Feng Shi, Yuanlong Chen, Xiumei Zhao   +4 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

The distribution of ATP within tomato (Lycopersicon esculentum Mill.) embryos correlates with germination whee as total ATP concentration does not

, 2002
The distribution of ATP in tomato seeds was visualized by monitoring the luminescence of frozen sections on top of a gel containing all the components of the luciferase reaction, but excluding ATP.
Joosen, R.V.L., Hilhorst, H.W.M., Spoelstra, P.   +2 more
core   +1 more source

Enhancing Bean (Phaseolus vulgaris L.) Resilience: Unveiling the Role of Halopriming against Saltwater Stress

Seeds
Common bean (Phaseolus vulgaris L.), one of the most important cultivated legumes, requires a high level of water. It is included among the most sensitive species to climate change; drought and salinity cause a reduction in photosynthesis, metabolic and ...
Ilaria Borromeo, Fabio Domenici, Cristiano Giordani, Maddalena Del Gallo, Cinzia Forni   +4 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Direct extraction of oil from sunflower seeds by twin-screw extruder according to an aqueous extraction process: Feasibility study and influence of operating conditions [PDF]

, 2007
The objective of this study was to evaluate the feasibility of an aqueous process to extract sunflower seed oil using a co-rotating twin-screw extruder. Aqueous extraction was carried out using whole seeds and the influence of the operating conditions on
Evon, Philippe, Pontalier, Pierre Yves, Ph. Evon, V. Vandenbossche, P.Y. Pontalier, Pontalier, Pierre-Yves, L. Rigal, Vandenbossche, Virginie, Rigal, Luc   +8 more
core   +1 more source

SEMIPERMEABILITY OF SEED COVERINGS AND STIMULATION OF SEEDS [PDF]

Plant Physiology, 1927
In a previous paper (6) the writer assumed that the methods of seed stimulation, advocated by Popoff (9) are of little value for agriculture and horticulture [cf. also Bredeman (1)]. Many publications witness the great interest on the subject of seed stimulation.
openaire   +2 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source