Results 121 to 130 of about 2,973,774 (400)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Optimizing Germination, Growth, and Antioxidant Potential of Aegopodium podagraria L. Under Different LED Light Spectra

open access: yesSeeds
Aegopodium podagraria (A. podagraria) L. is a perennial herb valued for its medicinal properties but exhibits poor germination and inconsistent growth under conventional cultivation.
Birtukan Tolera Geleta, Jae-Yun Heo
doaj   +1 more source

US Residential Energy Demand and Energy Efficiency: A Stochastic Demand Frontier Approach [PDF]

open access: yes
This paper estimates a US ‘frontier’ residential aggregate energy demand function using panel data for 48 ‘states’ over the period 1995 to 2006 using stochastic frontier analysis (SFA). Utilizing an econometric energy demand model, the (in) efficiency of
Lester C Hunt, Massimo Filippini
core  

Strength through diversity: how cancers thrive when clones cooperate

open access: yesMolecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken   +3 more
wiley   +1 more source

Seed Nanopriming Improves Jalapeño Pepper Seedling Quality for Transplantation

open access: yesSeeds
Nanopriming with metal nanoparticles (NPs) is a promising strategy for improving seedling quality in horticultural crops. This study evaluated the effects of hydropriming, ZnO, SiO2, ZnO + SiO2, a ZnMo nanofertilizer, and two commercial biostimulants ...
Erick H. Ochoa-Chaparro   +5 more
doaj   +1 more source

Can the North Sea Still Save Europe? [PDF]

open access: yes
In the 1980s and 1990s the North Sea emerged as a key non-OPEC oil producing province. Yet today overall production is declining, in both the British and Norwegian sectors and the big oil companies and investors are losing interest in what they now see ...
Carole Nakhle
core  

Next‐generation proteomics improves lung cancer risk prediction

open access: yesMolecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj   +4 more
wiley   +1 more source

Escaping Maturation Stress: Late Sowing as a Strategy to Secure High-Vigor Soybean Seeds in Subtropical Low-Altitude Environments

open access: yesSeeds
Soybean seed production in low-altitude subtropical environments in Paraguay is constrained by the antagonism between achieving high grain yields and high physiological seed quality, a relationship governed by the Genotype x Environment x Management ...
Jose Ricardo Bagateli   +5 more
doaj   +1 more source

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