Results 121 to 130 of about 1,762,405 (367)
Molecular Oncology, EarlyView.Cancer stem cells are associated with aggressive disease, but a deep characterization of such markers is lacking in endometrial cancer. This study uses imaging mass cytometry to explore putative cancer stem cell markers in endometrial tumors and corresponding organoid models.
Hilde E. Lien +7 more
wiley +1 more source
Multiple sclerosis clinical decision support system based on projection to reference datasets
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1863-1873, December 2022., 2022 Abstract Objective Multiple sclerosis (MS) is a multifactorial disease with increasingly complicated management. Our objective is to use on‐demand computational power to address the challenges of dynamically managing MS. Methods A phase 3 clinical trial data (NCT00906399) were used to contextualize the medication efficacy of peg‐interferon beta‐1a vs ...
Chadia Ed‐driouch +13 more
wiley +1 more source
Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression
Molecular Oncology, EarlyView.Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park +6 more
wiley +1 more source
Harmonizing results of ataxia rating scales: mFARS, SARA, and ICARS
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 2041-2046, December 2022., 2022 Abstract The ever‐increasing body of ataxia research provides opportunities for large‐scale meta‐analyses, systematic reviews, and data aggregation. Because multiple standardized scales are used to quantify ataxia severity, harmonization of these measures is necessary for quantitative data pooling. We applied the modified Friedreich Ataxia Rating Scale
Christian Rummey +5 more
wiley +1 more source
Good Seed Makes a Good Crop: Discovering Secret Seeds in Text-to-Image Diffusion Models [PDF]
arXivRecent advances in text-to-image (T2I) diffusion models have facilitated creative and photorealistic image synthesis. By varying the random seeds, we can generate many images for a fixed text prompt. Technically, the seed controls the initial noise and, in multi-step diffusion inference, the noise used for reparameterization at intermediate timesteps ...
arxiv
Effects of population- and seed bank noise on neutral evolution and efficacy of natural selection [PDF]
arXiv, 2017 Population genetics models typically consider a fixed population size and a unique selection coefficient. However, population dynamics inherently generate noise in numbers of individuals and selection acts on various components of the individuals' fitness.
arxiv
Quantifying the Impact of Exogenous Non-Economic Factors on UK Transport Oil Demand [PDF]
This paper attempts to quantify the impact of exogenous non-economic factors on UK transport oil demand (in addition to income, price, and fuel efficiency) by estimating the demand relationship for oil transport for 1960-2007 using the Structural Time ...
David C Broadstock, Lester C Hunt
core
Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance
Molecular Oncology, EarlyView.Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren +4 more
wiley +1 more source
SEMIPERMEABILITY OF SEED COVERINGS AND STIMULATION OF SEEDS [PDF]
Plant Physiology, 1927 In a previous paper (6) the writer assumed that the methods of seed stimulation, advocated by Popoff (9) are of little value for agriculture and horticulture [cf. also Bredeman (1)]. Many publications witness the great interest on the subject of seed stimulation.
openaire +3 more sources
Modelling Technical Progress: An Application of the Stochastic Trend Model to UK Energy Demand [PDF]
The precise role of technical progress in estimated energy demand functions has not been well researched. Traditionally a deterministic time trend has been used, implicitly assuming technical progress continues at a fixed rate over time.
Guy Judge +2 more
core