Results 91 to 100 of about 462,162 (384)
Identification of novel small molecule inhibitors of ETS transcription factors
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla+9 more
wiley +1 more source
John Martin’s paintings of biblical catastrophe met with a sensational response from the viewing public. Early in his career he was employed as a glass painter and this article examines the potential connection between this and Martin’s dramatically ...
Sally Rush
doaj +2 more sources
The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum
In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti+3 more
wiley +1 more source
The Spectrum of HD 3651B: An Extrasolar Nemesis? [PDF]
This article has been withdrawn; see astro-ph ...
arxiv
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
Criticality versus q in the 2+1-dimensional $Z_q$ clock model [PDF]
Paper has been withdrawn, see comment.
arxiv
Seeing Through the Clouds With DeepWaterMap
We present our next-generation surface water mapping model, DeepWaterMapV2, which uses improved model architecture, data set, and a training setup to create surface water maps at lower cost, with higher precision and recall. We designed DeepWaterMapV2 to
Leo F. Isikdogan+2 more
semanticscholar +1 more source
Social context prevents heat hormetic effects against mutagens during fish development
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere+5 more
wiley +1 more source
"The Familiar Physiognomy of a Word": Wittgenstein on Seeing Faces and Words
The second part of Philosophical Investigations and other contemporary writings contain abundant material dedicated to the examination of visual perception, along the lines of similarities and differences manifested in the use of concepts such as “seeing
Silvia Carolina Scotto
doaj +1 more source