Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
The phonological deficit in developmental dyslexia : is there a suprasegmental component? [PDF]
, 2007 Adult dyslexics were tested on a range of tasks\ud which were presented in two closely matched\ud versions: a segmental version and a\ud suprasegmental version. The tasks targeted\ud phonological contrasts on one hand and the\ud metalinguistic ability to
Ota, Mitsuhiko +2 more
core
Online-based intelligibility instruction for second language (L2) learners
, 2022 As speaking skills in English have become increasingly important in different academic and professional venues as a result of globalization, the issues of intelligibility and comprehensibility which go to the very core of global communication have come ...
Dalman, Mohammadreza
core
Does Musicality Assist Foreign Language Learning? Perception and Production of Thai Vowels, Consonants and Lexical Tones by Musicians and Non-Musicians. [PDF]
Brain Sci, 2023 Götz A, Liu L, Nash B, Burnham D.
europepmc +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Condicions prosòdiques i minimitat en el tipus reduplicatiu 'puput' [PDF]
, 1995 El propòsit d'aquest treball és descriure el procés morfològic de reduplicació parcial que ha format una sèrie de mots del català, agrupats sota el que anomenem tipus puput.
Cabré Monné, Teresa
core
Survey of the Teaching of Pronunciation in Adult ESL Programs in Canada, 2010
, 2012 This follow-up study reexamines the state of the teaching of pronunciation in ESL classes across Canada. The purpose of the survey was twofold: to gain a snapshot of current practices and to compare this with the picture of 10 years ago.
Foote, Jennifer A. +2 more
core +1 more source
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells
FEBS Open Bio, EarlyView.RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour +2 more
wiley +1 more source