Results 81 to 90 of about 919,853 (340)

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Data Balancing Based on Pre-Training Strategy for Liver Segmentation from CT Scans

Applied Sciences, 2019
Data imbalance is often encountered in deep learning process and is harmful to model training. The imbalance of hard and easy samples in training datasets often occurs in the segmentation tasks from Contrast Tomography (CT) scans.
Yong Zhang, Yi Wang, Yizhu Wang, Bin Fang, Wei Yu, Hongyu Long, Hancheng Lei   +6 more
doaj   +1 more source

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

Molecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane, Jérôme Ambroise, Cédric van Marcke, Mieke Van Bockstal, Martine Berlière, Christine Galant, Hélène Dano, Médina Lougué, Elena Benidovskaya, Guy Jerusalem, Vincent Bours, Claire Josse, Jérôme Thiry, Aurélie Daumerie, Caroline Bouzin, Cyril Corbet, François P. Duhoux   +16 more
wiley   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Non Negative Matrix Factorization Clustering Capabilities; Application on Multivariate Image Segmentation [PDF]

Journal of Electrical and Electronics Engineering, 2009
The clustering capabilities of the Non Negative MatrixFactorization algorithm is studied. The basis images are consideredlike the data membership degree to a particular class.A hard clustering algorithm is easily derived based on theseimages.
Cosmin Lazar, Danielle Nuzillard, Patrice Billaudel, Sorin Curila   +3 more
doaj  

Development of writing task recombination technology based on DMP segmentation via verbal command for Baxter robot

Systems Science & Control Engineering, 2018
This paper developed a character recombination technology based on dynamic movement primitive (DMP) segmentation using verbal command on a Baxter robot platform. Movements are recorded from a human demonstrator.
Chunxu Li, Chenguang Yang, Andy Annamalai, Qingsong Xu, Shaoxiang Li   +4 more
doaj   +1 more source

Automatic Parametrization and Shadow Analysis of Roofs in Urban Areas from ALS Point Clouds with Solar Energy Purposes

ISPRS International Journal of Geo-Information, 2018
A basic feature of modern and smart cities is their energetic sustainability, using clean and renewable energies and, therefore, reducing the carbon emissions, especially in large cities. Solar energy is one of the most important renewable energy sources,
Mario Soilán, Belén Riveiro, Patricia Liñares, Marta Padín-Beltrán   +3 more
doaj   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Tracing Actin Filament Bundles in Three-Dimensional Electron Tomography Density Maps of Hair Cell Stereocilia

Molecules, 2018
Cryo-electron tomography (cryo-ET) is a powerful method of visualizing the three-dimensional organization of supramolecular complexes, such as the cytoskeleton, in their native cell and tissue contexts. Due to its minimal electron dose and reconstruction
Salim Sazzed, Junha Song, Julio A. Kovacs, Willy Wriggers, Manfred Auer, Jing He   +5 more
doaj   +1 more source