Results 51 to 60 of about 15,556 (304)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Simulation of the optical performance of the Fluorescence detector Array of Single-pixel Telescopes [PDF]

EPJ Web of Conferences, 2019
The Fluorescence detector Array of Single-pixel Telescopes (FAST) is a proposed large-area, next-generation experiment for the detection of ultra-high energy cosmic rays via the atmospheric fluorescence technique. The telescope’s large field-of-view (30 ×
Pech Miroslav, Albury Justin, Bellido Jose A., Farmer John, Fujii Toshihiro, Hamal Petr, Horvath Pavel, Hrabovsky Miroslav, Chytka Ladislav, Malacari Max, Mandat Dusan, Matthews John N., Ni Xiaochen, Nozka Libor, Palatka Miroslav, Privitera Paolo, Schovanek Petr, Thomas Stan B., Travnicek Petr   +18 more
doaj   +1 more source

Bionic Covert Underwater Acoustic Communication Based on Time–Frequency Contour of Bottlenose Dolphin Whistle

Entropy, 2022
In order to meet the requirements of communication security and concealment, as well as to protect marine life, bionic covert communication has become a hot research topic for underwater acoustic communication (UAC).
Lei Xie, Jiahui Zhu, Yuqing Jia, Huifang Chen   +3 more
doaj   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Segmented Mirror Telescope, NPS space systems group acquires cutting edge technology [video] [PDF]

, 2010
Segmented Mirror Telescope, NPS space systems group acquires cutting edge technology.
Naval Postgraduate School
core  

Bessel beam generation using a segmented deformable mirror [PDF]

, 2018
Bessel beams with tunable spot size are desirable for many applications such as laser material processing, optical trapping, and imaging. In this paper, we report experimental and simulation results of using a segmented deformable mirror to generate zero-
Hongmei Tang, Ankesh Todi, Yu, Xiaoming, Xiaoming Yu, Tang, Hongmei, Todi, Ankesh   +5 more
core   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

System Estimates Radius of Curvature of a Segmented Mirror [PDF]

, 2008
A system that estimates the global radius of curvature (GRoC) of a segmented telescope mirror has been developed for use as one of the subsystems of a larger system that exerts precise control over the displacements of the mirror segments.
Rakoczy, John
core   +1 more source