Results 91 to 100 of about 23,265,687 (345)
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
A Demonstration of Wavefront Sensing and Mirror Phasing from the Image Domain [PDF]
, 2014 In astronomy and microscopy, distortions in the wavefront affect the dynamic range of a high contrast imaging system. These aberrations are either imposed by a turbulent medium such as the atmosphere, by static or thermal aberrations in the optical path,
Cheetham, Anthony +5 more
core +2 more sources
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Simplified Model of Segmented Electrode Losses in Nonequilibrium MHD Generators [PDF]
Simplified model of segmented electrode losses in nonequilibrium magnetohydrodynamic ...
Hoffman, M. A.
core +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
DISTINGUISHING BETWEEN EQUILIBRIUM AND INTEGRATION IN MARKETS ANALYSIS [PDF]
This paper introduces a new market analysis methodology based on maximum likelihood estimation of a mixture distribution model incorporating price, transfer cost, and trade flow data. Not only does this method obviate statistical problems associated with
Barrett, Christopher B., Li, Jau-Rong
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
A SEGMENTED REGRESSION MODEL FOR DESCRIPTION OF MICROBIAL GROWTH [PDF]
Journal of Sciences, Islamic Republic of Iran, 1999 A segmented regression model for the description of microbial growth has been suggested. The model is able to predict the exponential growth, logistic growth, logistic growth with a phase of decline, diauxic growth, microbial growth in synchronous ...
doaj
Choosy search and the mismatch of talents [PDF]
This paper proposes a multi-sector matching model where workers have (symmetric) sector-specific skills and the search market is segmented by sector. Workers choose the range of markets they are willing to participate in.
Decreuse, Bruno
core +1 more source
Exploring Segment Representations for Neural Segmentation Models
, 2016 Many natural language processing (NLP) tasks can be generalized into segmentation problem. In this paper, we combine semi-CRF with neural network to solve NLP segmentation tasks. Our model represents a segment both by composing the input units and embedding the entire segment.
Liu, Yijia +4 more
openaire +2 more sources