Results 31 to 40 of about 1,004,783 (271)

Le Barrio, une figure majeure du quartier aux États-Unis

Cahiers des Amériques Latines, 2008
This paper investigates the interpenetration of Hispanic and Anglo worlds in Northern American cities and focuses on the rise of Hispanic neighborhoods (or Barrios) that resulted from massive waves of Hispanic immigration.
Sonia Lehman-frisch
doaj   +1 more source

Quantification of segregation dynamics in ice mixtures

, 2009
(Abridged) The observed presence of pure CO2 ice in protostellar envelopes is attributed to thermally induced ice segregation, but a lack of quantitative experimental data has prevented its use as a temperature probe. Quantitative segregation studies are
Bergin, Bergin, Bernstein, Bouwman, Chiar, Collings, Collings, Cuppen, Dartois, E. C. Fayolle, E. F. van Dishoeck, Ehrenfreund, Ehrenfreund, Fuchs, Garrod, Gerakines, Gerakines, Gerakines, H. Linnartz, H. M. Cuppen, Hodyss, Ioppolo, Jenniskens, K. I. Öberg, Knez, Loeffler, Los, Los, Merrill, Nummelin, Palumbo, Pontoppidan, Pontoppidan, Sandford, Sonnentrucker, Teolis, Tielens, van Broekhuizen, Visser, Watanabe, Watanabe, Zasowski, Öberg, Öberg   +43 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Kif11-haploinsufficient oocytes reveal spatially differential requirements for chromosome biorientation

EMBO Reports
Bipolar spindle assembly and chromosome biorientation are prerequisites for chromosome segregation during cell division. The kinesin motor KIF11 (also widely known as Eg5) drives spindle bipolarization by sliding antiparallel microtubules bidirectionally,
Tappei Mishina, Aurélien Courtois, Shuhei Yoshida, Kohei Asai, Hiroshi Kiyonari, Tomoya S Kitajima   +5 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Evidence of substrate control of Cdk phosphorylation during the budding yeast cell cycle

Cell Reports
Summary: A series of sequential events orchestrates cell growth and division, set in motion by cyclin-dependent kinases (Cdks). In the “qualitative model” for Cdk control, order is achieved by cell cycle stage-specific cyclins.
Luca Takacs, Lina Gerontogianni, Kimberly Quililan, Helen Flynn, Frank Uhlmann   +4 more
doaj   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Frontières internes et mobilité résidentielle en Irlande du Nord

Espace populations sociétés, 2005
Though Northern Ireland’s boundaries are maintaining themselves physically, they are facing changes that collide with the historical tensions linked to the troubles.
Jennifer Heurley
doaj   +1 more source

Female participation increases and gender segregation. ESRI WP564, May 2017 [PDF]

, 2017
This article examines the impact of a large increase in female participation on occupational segregation. Increases in female participation may decrease occupational segregation if women enter male dominated sectors but may increase segregation if they ...
Keane, Claire, Russell, Helen, Smyth, Emer   +2 more
core