Results 91 to 100 of about 338,240 (315)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Case report: Bridging limbic network epilepsy with psychiatric, memory, and sleep comorbidities: case illustrations of reversible psychosis symptoms during continuous, high-frequency ANT-DBS

Frontiers in Network Physiology
The network nature of focal epilepsy is exemplified by mesial temporal lobe epilepsy (mTLE), characterized by focal seizures originating from the mesial temporal neocortex, amygdala, and hippocampus.
Lydia Wheeler, Lydia Wheeler, Samuel E. Worrell, Irena Balzekas, Irena Balzekas, Jordan Bilderbeek, Dora Hermes, Paul Croarkin, Steven Messina, Jamie Van Gompel, Kai J. Miller, Vaclav Kremen, Vaclav Kremen, Vaclav Kremen, Gregory A. Worrell, Gregory A. Worrell   +15 more
doaj   +1 more source

Topographic distribution of seizure patterns in patients with absence epilepsy

, 2022
Background: Absence seizures, which are also known as petit mal seizures, are the most common type of seizures in pediatric epilepsy. They appear in several types of epilepsy and are characterized by impaired consciousness and 3-Hz spike-and-slow-wave ...
Mazzaretto, Andrea
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Vitamin D content and prevalence of vitamin D deficiency in patients with epilepsy: a systematic review and meta-analysis

Frontiers in Nutrition
IntroductionThe prevalence of vitamin D deficiency and vitamin D levels in patients with epilepsy (PWE) were systematically evaluated, and the differences between subgroups were analyzed.MethodWe identified all articles investigating the prevalence of ...
Yuanyuan Liu, Chao Gong, Jiawei Li, Xin Ning, Pei Zeng, Luchuan Wang, Beibei Lian, Jiahao Liu, Liya Fang, Jin Guo, Jin Guo   +10 more
doaj   +1 more source

Seizure- and syncope-related head injuries in children: A prospective PREDICT cohort study

, 2021
Seizure- and syncope-related head injuries in children: A prospective PREDICT cohort ...
S Bressan (7739435), FE Babl (7746314), MD Lyttle (7746329), SR Dalziel (7746350), A Kochar (7746572), JA Cheek (7746311), A Williams (4236469), N Phillips (7746563), J Neutze (7746551), Jeremy Furyk (13069986), N Eapen (13424166), S Hearps (13363587), ML Borland (14465448), E Oakley (7746317)   +13 more
core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Long-term outcomes of surgical treatment for epilepsy in adults with regard to seizures, antiepileptic drug treatment and employment

, 2017
There is Class I evidence for short-term efficacy of epilepsy surgery from two randomized controlled studies of temporal lobe resection. Long-term outcome studies are observational.
Edelvik, Anna,, Malmgren, Kristina,
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Neurocysticercosis detected by targeted next-generation sequencing of cerebrospinal fluid: a case report

Frontiers in Neurology
The patient, a middle-aged male with a long history of the disease, had experienced recurrent headaches for 26 years and episodic shaking of the right limb with slurred speech for the past month.
Xintong Ren, HuiQin Sun, Yanghong Cheng, Yunzhou Zhang, Daiquan Gao   +4 more
doaj   +1 more source