Results 101 to 110 of about 589,280 (296)

Predicting Seizure Risk from Routine Electroencephalographs in Medical Intensive Care Units Using the 2HELPS2B Score

Life
This study evaluated the utility of the 2HELPS2B score in predicting seizures from routine electroencephalographs (rEEGs). In total, 670 rEEGs obtained in a medical intensive care unit (MICU) between October 2018 and March 2023 were analyzed.
Cheng-Lun Hsiao, Wan-Ling Chang, Pei-Ya Chen, I-An Chen, Shinn-Kuang Lin   +4 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Comparative Analysis of Seizure Clusters in Patients with and Without a History of Epilepsy Presenting to the Emergency Department

NeuroSci
Seizure clusters can be observed in patients with epilepsy as well as in individuals without a previous history of epilepsy. However, there are no data on whether seizure clusters differ between these two populations.
Silvio Basic, Ivana Basic, Ivana Susak Sporis, Davor Sporis, Jelena Saric Juric, Petra Meznaric   +5 more
doaj   +1 more source

Nasal pregabalin overdose and myclonus: a new way of misuse

Psychiatry and Clinical Psychopharmacology, 2019
Pregabalin reduces central neuronal excitability and has gamma-aminobutyric acid-mimetic features, which was demonstrated in rats. Pregabalin is indicated for the treatment of neuropathic pain, post-herpetic neuralgia, fibromyalgia and partial seizures ...
H. Mihrimah Ozturk, Gülin Morkavuk
doaj   +1 more source

ΔFosB Regulates Gene Expression and Cognitive Dysfunction in a Mouse Model of Alzheimer\u27s Disease. [PDF]

, 2017
Alzheimer\u27s disease (AD) is characterized by cognitive decline and 5- to 10-fold increased seizure incidence. How seizures contribute to cognitive decline in AD or other disorders is unclear.
Aschmies, Suzan, Ashok, Annie, Chin, Jeannie, Corbett, Brian F, Fu, Chia-Hsuan, Hazra, Anupam, Iascone, Daniel M, Nestler, Eric J, Petrof, Iraklis, Pyfer, Mark S, Stephens, Gabriel S, Tosi, Umberto, You, Jason C, Zhang, Xiaohong, Zhao, Lijuan   +14 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Assessment of benzodiazepine dosing in status epilepticus patients in the emergency department

Frontiers in Neurology
BackgroundStatus epilepticus (SE) is a medical emergency that requires immediate care and is associated with substantial mortality and morbidity. Current guidelines recommend benzodiazepines (BZDs), regardless of the type of SE, as an initial treatment ...
Raniah Ibrahim Aljadeed, Amenah Alkaf, Daad Alhajlbrahim, Huda Alewairdhi, Ghadah Asaad Assiri, Rana Aljadeed, Haya Almalag, Nora Kalagi   +7 more
doaj   +1 more source

Anticonvulsant Effect of Hydroalcoholic Extract of Scrophularia Striata Boiss. on Pentylenetetrazol-Induced Seizure in Mice [PDF]

Journal of Kerman University of Medical Sciences, 2014
Background & Aims: Epilepsy is a central nervous system disorder that appears as sudden convulsions, and transient, repetitive and unpredictable movment, with sensory-motor and autonomic sources.
B Alimohammadi, H Azhdari-Zarmehri, M Sofiabadi, A.R Moslem   +3 more
doaj  

Is there something special about cardiovascular abnormalities and sudden unexpected death in epilepsy among patients with chronic renal insufficiency in regular hemodialysis program? Existe algo de especial a respeito das anormalidades cardíacas e morte súbita e inesperada na epilepsia nos pacientes com insuficiência renal crônica no programa regular de hemodiálise?

Arquivos de Neuro-Psiquiatria, 2009
Of the many risk factors suggested for sudden unexpected death in epilepsy (SUDEP), higher frequency of seizures is a very consistent issue. Following this reasoning, it has been established that hemodialysis-associated seizure is a complication of ...
Rui A. Gomes, Silvana Kesrouani, Jenner Cruz, Alexandre L. Silva, Tânia M.G. Henriques, Marly de Albuquerque, Ricardo M. Arida, Eliza Y.F. Sonoda, Roberta M. Cysneiros, Vera C. Terra, Carla A. Scorza, Esper A. Cavalheiro, Fulvio A. Scorza   +12 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source